BRD-K05396879_15-delta prostaglandin J2_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K05396879_15-delta prostaglandin J2_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
CA1 carbonic anhydrase I
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD1 chromodomain helicase DNA binding protein 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CSRP1 cysteine and glycine-rich protein 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSE dermatan sulfate epimerase
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
FNDC3A fibronectin type III domain containing 3A
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP13 matrix metallopeptidase 13
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUPL1 nucleoporin like 1
PDE8A phosphodiesterase 8A
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TBPL1 TBP-like 1
TES testin LIM domain protein
TOX3 TOX high mobility group box family member 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ARHGAP29 Rho GTPase activating protein 29
ATF5 activating transcription factor 5
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CCDC85B coiled-coil domain containing 85B
CCNF cyclin F
CD9 CD9 molecule
CLDN1 claudin 1
CRIP1 cysteine-rich protein 1 (intestinal)
CST1 cystatin SN
CST4 cystatin S
CXADR coxsackie virus and adenovirus receptor
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLD dihydrolipoamide dehydrogenase
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM3C family with sequence similarity 3, member C
FZD7 frizzled class receptor 7
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KRT14 keratin 14, type I
KRT16 keratin 16, type I
LAMP5 lysosomal-associated membrane protein family, member 5
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MKL2 MKL/myocardin-like 2
MTCH2 mitochondrial carrier 2
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
OPHN1 oligophrenin 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRAME preferentially expressed antigen in melanoma
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A7 S100 calcium binding protein A7
SCD5 stearoyl-CoA desaturase 5
SFRP1 secreted frizzled-related protein 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TNS3 tensin 3
ZNF185 zinc finger protein 185 (LIM domain)