BRD-K05396879_15-delta prostaglandin J2_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K05396879_15-delta prostaglandin J2_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADRB2 adrenoceptor beta 2, surface
APOC1 apolipoprotein C-I
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CTSZ cathepsin Z
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FAS Fas cell surface death receptor
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL7R interleukin 7 receptor
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM6B lysine (K)-specific demethylase 6B
LBH limb bud and heart development
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MT1M metallothionein 1M
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG3 paternally expressed 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAP prosaposin
PTN pleiotrophin
S100A8 S100 calcium binding protein A8
SCG5 secretogranin V
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
TMEM176B transmembrane protein 176B
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AURKB aurora kinase B
BTBD3 BTB (POZ) domain containing 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CHGB chromogranin B
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DLD dihydrolipoamide dehydrogenase
EDNRB endothelin receptor type B
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA5 homeobox A5
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMB1 laminin, beta 1
LRRC17 leucine rich repeat containing 17
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCAM melanoma cell adhesion molecule
MGP matrix Gla protein
MYH10 myosin, heavy chain 10, non-muscle
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRN1 neuritin 1
PEG10 paternally expressed 10
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PLN phospholamban
PLP1 proteolipid protein 1
PLS3 plastin 3
PNMA2 paraneoplastic Ma antigen 2
PODXL podocalyxin-like
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PTTG1 pituitary tumor-transforming 1
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SEC14L1 SEC14-like 1 (S. cerevisiae)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STOM stomatin
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb
ZCCHC24 zinc finger, CCHC domain containing 24