BRD-K05331696_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K05331696_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ADAM9 ADAM metallopeptidase domain 9
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCAP31 B-cell receptor-associated protein 31
BIN1 bridging integrator 1
BRD4 bromodomain containing 4
CBR3 carbonyl reductase 3
CDC14B cell division cycle 14B
CDCP1 CUB domain containing protein 1
CES1 carboxylesterase 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
ECM1 extracellular matrix protein 1
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GARS glycyl-tRNA synthetase
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPC1 glypican 1
GPX2 glutathione peroxidase 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2AFY H2A histone family, member Y
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGLL1 immunoglobulin lambda-like polypeptide 1
IL6R interleukin 6 receptor
ITGB5 integrin, beta 5
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KLF5 Kruppel-like factor 5 (intestinal)
KTN1 kinectin 1 (kinesin receptor)
KYNU kynureninase
LCN2 lipocalin 2
LMO4 LIM domain only 4
LRP10 low density lipoprotein receptor-related protein 10
LTBP3 latent transforming growth factor beta binding protein 3
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP3 matrix metallopeptidase 3
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PGD phosphogluconate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLEC plectin
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RYBP RING1 and YY1 binding protein
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD3 SMAD family member 3
SOWAHC sosondowah ankyrin repeat domain family member C
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TALDO1 transaldolase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGOLN2 trans-golgi network protein 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TUBA4A tubulin, alpha 4a
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX1 armadillo repeat containing, X-linked 1
ARMT1 acidic residue methyltransferase 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BCHE butyrylcholinesterase
C3 complement component 3
C7 complement component 7
CD200 CD200 molecule
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
COL3A1 collagen, type III, alpha 1
COX11 COX11 cytochrome c oxidase copper chaperone
CSTA cystatin A (stefin A)
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DLD dihydrolipoamide dehydrogenase
DNALI1 dynein, axonemal, light intermediate chain 1
DPYSL2 dihydropyrimidinase-like 2
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
GINS1 GINS complex subunit 1 (Psf1 homolog)
GTPBP8 GTP-binding protein 8 (putative)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
KIAA1467 KIAA1467
KRT81 keratin 81, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
MANSC1 MANSC domain containing 1
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MUC1 mucin 1, cell surface associated
NBN nibrin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOV nephroblastoma overexpressed
OAT ornithine aminotransferase
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLS1 plastin 1
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
PSPH phosphoserine phosphatase
PWP1 PWP1 homolog (S. cerevisiae)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS10 regulator of G-protein signaling 10
RTN1 reticulon 1
S100A4 S100 calcium binding protein A4
SCGB1D2 secretoglobin, family 1D, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SPDEF SAM pointed domain containing ETS transcription factor
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCEA2 transcription elongation factor A (SII), 2
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TMEM14A transmembrane protein 14A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UBE2N ubiquitin-conjugating enzyme E2N
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1