BRD-K05331696_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K05331696_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FLNA filamin A, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGKC immunoglobulin kappa constant
KDM5D lysine (K)-specific demethylase 5D
KRT6A keratin 6A, type II
KYNU kynureninase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PENK proenkephalin
PIR pirin (iron-binding nuclear protein)
PITRM1 pitrilysin metallopeptidase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC2 stanniocalcin 2
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALB albumin
BICC1 BicC family RNA binding protein 1
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CAST calpastatin
CD24 CD24 molecule
CES2 carboxylesterase 2
CHGB chromogranin B
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FSTL1 follistatin-like 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
KRT23 keratin 23, type I
LITAF lipopolysaccharide-induced TNF factor
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PPAP2A phosphatidic acid phosphatase type 2A
PTCH1 patched 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS5 regulator of G-protein signaling 5
SDC2 syndecan 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SST somatostatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRIM22 tripartite motif containing 22
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble