BRD-K05331696_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K05331696_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSM3 acyl-CoA synthetase medium-chain family member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLU clusterin
CREM cAMP responsive element modulator
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP10 matrix metallopeptidase 10
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
ODC1 ornithine decarboxylase 1
PCP4 Purkinje cell protein 4
PIR pirin (iron-binding nuclear protein)
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCB protein kinase C, beta
RABGAP1L RAB GTPase activating protein 1-like
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APP amyloid beta (A4) precursor protein
ARHGAP29 Rho GTPase activating protein 29
ASRGL1 asparaginase like 1
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CELF2 CUGBP, Elav-like family member 2
CLDN8 claudin 8
CNN3 calponin 3, acidic
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTGF connective tissue growth factor
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP6 dual specificity phosphatase 6
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KCTD12 potassium channel tetramerization domain containing 12
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LPL lipoprotein lipase
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAM melanoma cell adhesion molecule
MMP9 matrix metallopeptidase 9
NFIB nuclear factor I/B
NRN1 neuritin 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PEG10 paternally expressed 10
PLK2 polo-like kinase 2
PTCH1 patched 1
S100A10 S100 calcium binding protein A10
SFRP1 secreted frizzled-related protein 1
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
TAGLN2 transgelin 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK2 tousled-like kinase 2
TNS3 tensin 3
VCAN versican
ZNF91 zinc finger protein 91