BRD-K05323277_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K05323277_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AP3D1 adaptor-related protein complex 3, delta 1 subunit
CA2 carbonic anhydrase II
CCND2 cyclin D2
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
EPAS1 endothelial PAS domain protein 1
FGF9 fibroblast growth factor 9
G6PD glucose-6-phosphate dehydrogenase
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
H2BFS H2B histone family, member S (pseudogene)
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
INSR insulin receptor
KDM4B lysine (K)-specific demethylase 4B
MTSS1 metastasis suppressor 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PEG10 paternally expressed 10
PODXL podocalyxin-like
SMAD3 SMAD family member 3
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
TNS1 tensin 1
TPM1 tropomyosin 1 (alpha)
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CCNA2 cyclin A2
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHEK2 checkpoint kinase 2
DEFB1 defensin, beta 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
FAM63A family with sequence similarity 63, member A
FXYD3 FXYD domain containing ion transport regulator 3
GNPDA1 glucosamine-6-phosphate deaminase 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HMGB2 high mobility group box 2
HNMT histamine N-methyltransferase
ICAM3 intercellular adhesion molecule 3
IL1R1 interleukin 1 receptor, type I
LPAR1 lysophosphatidic acid receptor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANSC1 MANSC domain containing 1
MELK maternal embryonic leucine zipper kinase
PRDX4 peroxiredoxin 4
RNASE4 ribonuclease, RNase A family, 4
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
UBE2C ubiquitin-conjugating enzyme E2C
WFDC2 WAP four-disulfide core domain 2