BRD-K05197617_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K05197617_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ATF3 activating transcription factor 3
BLNK B-cell linker
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CES1 carboxylesterase 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC2B C-type lectin domain family 2, member B
CREB3L1 cAMP responsive element binding protein 3-like 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EMP1 epithelial membrane protein 1
ENAH enabled homolog (Drosophila)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM3C family with sequence similarity 3, member C
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
GYPC glycophorin C (Gerbich blood group)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IRF6 interferon regulatory factor 6
MEF2A myocyte enhancer factor 2A
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
NES nestin
NR1H2 nuclear receptor subfamily 1, group H, member 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PKM pyruvate kinase, muscle
PLAU plasminogen activator, urokinase
RGS16 regulator of G-protein signaling 16
RNF167 ring finger protein 167
RSL24D1 ribosomal L24 domain containing 1
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOCS2 suppressor of cytokine signaling 2
STX1A syntaxin 1A (brain)
TM9SF3 transmembrane 9 superfamily member 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM2 tripartite motif containing 2
VSNL1 visinin-like 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG2 adhesion G protein-coupled receptor G2
APLP2 amyloid beta (A4) precursor-like protein 2
ATP9A ATPase, class II, type 9A
CHPT1 choline phosphotransferase 1
CLU clusterin
CST3 cystatin C
DKK1 dickkopf WNT signaling pathway inhibitor 1
DYNLRB1 dynein, light chain, roadblock-type 1
FAM46A family with sequence similarity 46, member A
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
GPC3 glypican 3
GSTM3 glutathione S-transferase mu 3 (brain)
HN1 hematological and neurological expressed 1
IGFBP6 insulin-like growth factor binding protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCTD12 potassium channel tetramerization domain containing 12
NPY1R neuropeptide Y receptor Y1
POSTN periostin, osteoblast specific factor
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RBP1 retinol binding protein 1, cellular
S100A10 S100 calcium binding protein A10
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SORD sorbitol dehydrogenase
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TSPAN13 tetraspanin 13
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta