BRD-K05181463_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

31 genes differentially expressed following the BRD-K05181463_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADIPOQ adiponectin, C1Q and collagen domain containing
CD36 CD36 molecule (thrombospondin receptor)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LPL lipoprotein lipase
MSMO1 methylsterol monooxygenase 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SOX2 SRY (sex determining region Y)-box 2
SQLE squalene epoxidase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
VCAN versican

decreased expression

Symbol Name
CLCA1 chloride channel accessory 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
OLFM4 olfactomedin 4
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
SIK1 salt-inducible kinase 1