BRD-K05151076_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K05151076_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
CCBL2 cysteine conjugate-beta lyase 2
CFLAR CASP8 and FADD-like apoptosis regulator
CRIP2 cysteine-rich protein 2
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FAM129A family with sequence similarity 129, member A
FBP1 fructose-1,6-bisphosphatase 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
JMJD1C jumonji domain containing 1C
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAV2 neuron navigator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NES nestin
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTS neurotensin
PCSK5 proprotein convertase subtilisin/kexin type 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PYGB phosphorylase, glycogen; brain
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SQSTM1 sequestosome 1
TACSTD2 tumor-associated calcium signal transducer 2
TNC tenascin C
TRIB3 tribbles pseudokinase 3
TXNDC9 thioredoxin domain containing 9

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA2 annexin A2
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
CA2 carbonic anhydrase II
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CTSG cathepsin G
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FRZB frizzled-related protein
GRWD1 glutamate-rich WD repeat containing 1
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
ISOC1 isochorismatase domain containing 1
ITM2C integral membrane protein 2C
MN1 meningioma (disrupted in balanced translocation) 1
MPPED2 metallophosphoesterase domain containing 2
OPHN1 oligophrenin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
REEP5 receptor accessory protein 5
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
SFRP1 secreted frizzled-related protein 1
SORBS3 sorbin and SH3 domain containing 3
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
VCAN versican