BRD-K05104363_PD-184352_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K05104363_PD-184352_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
EMX2 empty spiracles homeobox 2
EPHB2 EPH receptor B2
FABP1 fatty acid binding protein 1, liver
FGFR3 fibroblast growth factor receptor 3
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
MATN2 matrilin 2
METTL7A methyltransferase like 7A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB4 phospholipase C, beta 4
PNKP polynucleotide kinase 3'-phosphatase
QPRT quinolinate phosphoribosyltransferase
RGS2 regulator of G-protein signaling 2
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CPA3 carboxypeptidase A3 (mast cell)
CSNK1E casein kinase 1, epsilon
CSTA cystatin A (stefin A)
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAM3C family with sequence similarity 3, member C
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEM GTP binding protein overexpressed in skeletal muscle
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
IER2 immediate early response 2
IER3 immediate early response 3
IGL immunoglobulin lambda locus
JUNB jun B proto-oncogene
KRT17 keratin 17, type I
LIF leukemia inhibitory factor
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCAM melanoma cell adhesion molecule
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PSD3 pleckstrin and Sec7 domain containing 3
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SDC4 syndecan 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS3 transmembrane protease, serine 3
TNC tenascin C
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
UPP1 uridine phosphorylase 1
WFDC2 WAP four-disulfide core domain 2