BRD-K05104363_PD-184352_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

301 genes differentially expressed following the BRD-K05104363_PD-184352_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ACOT13 acyl-CoA thioesterase 13
ACSF2 acyl-CoA synthetase family member 2
ADD3 adducin 3 (gamma)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AGR2 anterior gradient 2
AIF1 allograft inflammatory factor 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX3 armadillo repeat containing, X-linked 3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
C1RL complement component 1, r subcomponent-like
C9ORF16 chromosome 9 open reading frame 16
CAT catalase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP6 charged multivesicular body protein 6
CLIC5 chloride intracellular channel 5
COX5B cytochrome c oxidase subunit Vb
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CRYL1 crystallin, lambda 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM13A family with sequence similarity 13, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD3 FXYD domain containing ion transport regulator 3
GAA glucosidase, alpha; acid
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GOLPH3L golgi phosphoprotein 3-like
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRAMD3 GRAM domain containing 3
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
HBP1 HMG-box transcription factor 1
HEPH hephaestin
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPA2 heat shock 70kDa protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGBP1 immunoglobulin (CD79A) binding protein 1
ITM2C integral membrane protein 2C
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT20 keratin 20, type I
KRT7 keratin 7, type II
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LXN latexin
LY75 lymphocyte antigen 75
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MKRN1 makorin ring finger protein 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NBR1 neighbor of BRCA1 gene 1
NCOA2 nuclear receptor coactivator 2
NEBL nebulette
NMRK1 nicotinamide riboside kinase 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
PNRC1 proline-rich nuclear receptor coactivator 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
PROS1 protein S (alpha)
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGC Ras-related GTP binding C
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SKAP2 src kinase associated phosphoprotein 2
SLC22A18 solute carrier family 22, member 18
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMC5 transmembrane channel-like 5
TMEM30B transmembrane protein 30B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSPAN3 tetraspanin 3
TSPAN31 tetraspanin 31
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TTC3 tetratricopeptide repeat domain 3
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
UBL3 ubiquitin-like 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCRB ubiquinol-cytochrome c reductase binding protein
VAMP8 vesicle-associated membrane protein 8
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WBP1L WW domain binding protein 1-like
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB10 zinc finger and BTB domain containing 10
ZFP36L2 ZFP36 ring finger protein-like 2
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIM2 absent in melanoma 2
AKAP12 A kinase (PRKA) anchor protein 12
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRIX1 BRX1, biogenesis of ribosomes
BYSL bystin-like
CANT1 calcium activated nucleotidase 1
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CPB1 carboxypeptidase B1 (tissue)
CTPS1 CTP synthase 1
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EREG epiregulin
EXO1 exonuclease 1
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FST follistatin
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HAL histidine ammonia-lyase
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JMJD6 jumonji domain containing 6
KIAA0020 KIAA0020
KIAA0101 KIAA0101
LMNB2 lamin B2
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SRM spermidine synthase
STK17A serine/threonine kinase 17a
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein