BRD-K05104363_PD-184352_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K05104363_PD-184352_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG2 BCL2-associated athanogene 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD58 CD58 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CRYAB crystallin, alpha B
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DIXDC1 DIX domain containing 1
DSP desmoplakin
EAPP E2F-associated phosphoprotein
EFNB2 ephrin-B2
FAM50A family with sequence similarity 50, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GATA6 GATA binding protein 6
GLS glutaminase
GOLGA8A golgin A8 family, member A
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
INSR insulin receptor
ISG15 ISG15 ubiquitin-like modifier
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAM3 junctional adhesion molecule 3
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PRDX2 peroxiredoxin 2
PROM1 prominin 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SC5D sterol-C5-desaturase
SEPT6 septin 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
SQLE squalene epoxidase
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
TFF3 trefoil factor 3 (intestinal)
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VLDLR very low density lipoprotein receptor
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASF1B anti-silencing function 1B histone chaperone
BRCA1 breast cancer 1, early onset
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL4 chemokine (C-C motif) ligand 4
CCND1 cyclin D1
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CP ceruloplasmin (ferroxidase)
CRISP3 cysteine-rich secretory protein 3
DHFR dihydrofolate reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ETV1 ets variant 1
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GMNN geminin, DNA replication inhibitor
GRB7 growth factor receptor-bound protein 7
GRIA2 glutamate receptor, ionotropic, AMPA 2
IL1R2 interleukin 1 receptor, type II
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KLK5 kallikrein-related peptidase 5
LIG1 ligase I, DNA, ATP-dependent
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON3 paraoxonase 3
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKD3 protein kinase D3
PTHLH parathyroid hormone-like hormone
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLPI secretory leukocyte peptidase inhibitor
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TFPI2 tissue factor pathway inhibitor 2
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein