BRD-K05104363_PD-184352_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K05104363_PD-184352_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACSL1 acyl-CoA synthetase long-chain family member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANG angiogenin, ribonuclease, RNase A family, 5
C1ORF115 chromosome 1 open reading frame 115
C5 complement component 5
C6ORF62 chromosome 6 open reading frame 62
CAT catalase
CCNG2 cyclin G2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CFB complement factor B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYTH1 cytohesin 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FZD5 frizzled class receptor 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GC group-specific component (vitamin D binding protein)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GOLGA8H golgin A8 family, member H
GSTA4 glutathione S-transferase alpha 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HPX hemopexin
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA2 heat shock 70kDa protein 2
KNG1 kininogen 1
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NCOA2 nuclear receptor coactivator 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NLRP2 NLR family, pyrin domain containing 2
NMRK1 nicotinamide riboside kinase 1
PAH phenylalanine hydroxylase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
RAP2A RAP2A, member of RAS oncogene family
RXRA retinoid X receptor, alpha
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53TG1 TP53 target 1 (non-protein coding)
TSKU tsukushi, small leucine rich proteoglycan
TST thiosulfate sulfurtransferase (rhodanese)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
BAG2 BCL2-associated athanogene 2
BMP4 bone morphogenetic protein 4
CBFB core-binding factor, beta subunit
CD200 CD200 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEMIP cell migration inducing protein, hyaluronan binding
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM216A family with sequence similarity 216, member A
FAM3C family with sequence similarity 3, member C
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
KRT18 keratin 18, type I
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSX1 msh homeobox 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAM peptidylglycine alpha-amidating monooxygenase
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMP22 peripheral myelin protein 22
PNO1 partner of NOB1 homolog (S. cerevisiae)
PRNP prion protein
PUS7 pseudouridylate synthase 7 (putative)
RBPMS RNA binding protein with multiple splicing
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
THBS2 thrombospondin 2
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM2 tripartite motif containing 2
UPP1 uridine phosphorylase 1
VCAN versican
ZEB1 zinc finger E-box binding homeobox 1