BRD-K05104363_PD-184352_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K05104363_PD-184352_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACSL1 acyl-CoA synthetase long-chain family member 1
AHNAK AHNAK nucleoprotein
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
C5AR1 complement component 5a receptor 1
CA12 carbonic anhydrase XII
CAST calpastatin
CD36 CD36 molecule (thrombospondin receptor)
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DYNLT1 dynein, light chain, Tctex-type 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP4 fatty acid binding protein 4, adipocyte
FILIP1L filamin A interacting protein 1-like
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GSTA1 glutathione S-transferase alpha 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HOXA5 homeobox A5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
LAMA3 laminin, alpha 3
LAMA4 laminin, alpha 4
LRRC16A leucine rich repeat containing 16A
LYN LYN proto-oncogene, Src family tyrosine kinase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OXTR oxytocin receptor
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP12 poly (ADP-ribose) polymerase family, member 12
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDPN podoplanin
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PON2 paraoxonase 2
PXDN peroxidasin
RBP1 retinol binding protein 1, cellular
RHOBTB3 Rho-related BTB domain containing 3
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFXN3 sideroflexin 3
SKAP2 src kinase associated phosphoprotein 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX4 SRY (sex determining region Y)-box 4
STK10 serine/threonine kinase 10
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN2 transgelin 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TKTL1 transketolase-like 1
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AREG amphiregulin
BPI bactericidal/permeability-increasing protein
CCND1 cyclin D1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS1B CDC28 protein kinase regulatory subunit 1B
CLC Charcot-Leyden crystal galectin
COL14A1 collagen, type XIV, alpha 1
COMP cartilage oligomeric matrix protein
CRLF1 cytokine receptor-like factor 1
CTSZ cathepsin Z
DENND2D DENN/MADD domain containing 2D
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
FOSL1 FOS-like antigen 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPM6B glycoprotein M6B
GRIA2 glutamate receptor, ionotropic, AMPA 2
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
IGF1 insulin-like growth factor 1 (somatomedin C)
IPO5 importin 5
ITGB1BP1 integrin beta 1 binding protein 1
ITM2A integral membrane protein 2A
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
NPY neuropeptide Y
NTS neurotensin
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKM pyruvate kinase, muscle
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPAP2B phosphatidic acid phosphatase type 2B
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC38A1 solute carrier family 38, member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPRY2 sprouty homolog 2 (Drosophila)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TTC3 tetratricopeptide repeat domain 3
USP1 ubiquitin specific peptidase 1
VEGFA vascular endothelial growth factor A