BRD-K04949373_Parthenolide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K04949373_Parthenolide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AK4 adenylate kinase 4
ARL4A ADP-ribosylation factor-like 4A
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
COLEC12 collectin sub-family member 12
CRABP1 cellular retinoic acid binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGF13 fibroblast growth factor 13
FZD7 frizzled class receptor 7
GPM6A glycoprotein M6A
H2BFS H2B histone family, member S (pseudogene)
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HRASLS HRAS-like suppressor
IDO1 indoleamine 2,3-dioxygenase 1
IL1R2 interleukin 1 receptor, type II
LYPD3 LY6/PLAUR domain containing 3
MMP3 matrix metallopeptidase 3
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDZK1IP1 PDZK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLIN2 perilipin 2
PROM1 prominin 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SERTAD2 SERTA domain containing 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
UGDH UDP-glucose 6-dehydrogenase
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASCL1 achaete-scute family bHLH transcription factor 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CORO1A coronin, actin binding protein, 1A
CYB561 cytochrome b561
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FKBP1A FK506 binding protein 1A, 12kDa
FSTL1 follistatin-like 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
KIAA0101 KIAA0101
KLHDC2 kelch domain containing 2
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MLPH melanophilin
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
PCNA proliferating cell nuclear antigen
PLAT plasminogen activator, tissue
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXDN peroxidasin
RFTN1 raftlin, lipid raft linker 1
RIN2 Ras and Rab interactor 2
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SMC1A structural maintenance of chromosomes 1A
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF1 serine/arginine-rich splicing factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM230 transmembrane protein 230
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNS3 tensin 3
TUBA1A tubulin, alpha 1a
TYMS thymidylate synthetase