BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA1 annexin A1
ANXA4 annexin A4
BASP1 brain abundant, membrane attached signal protein 1
C5AR1 complement component 5a receptor 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
CYBB cytochrome b-245, beta polypeptide
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV5 ets variant 5
FCGBP Fc fragment of IgG binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD5 frizzled class receptor 5
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
LEFTY1 left-right determination factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS1 Meis homeobox 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTSS1 metastasis suppressor 1
NAMPT nicotinamide phosphoribosyltransferase
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RIN2 Ras and Rab interactor 2
RNASE4 ribonuclease, RNase A family, 4
RPL36 ribosomal protein L36
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A11 S100 calcium binding protein A11
SALL1 spalt-like transcription factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
VEGFA vascular endothelial growth factor A
WSCD1 WSC domain containing 1

decreased expression

Symbol Name
AQP1 aquaporin 1 (Colton blood group)
COL10A1 collagen, type X, alpha 1
COL5A1 collagen, type V, alpha 1
CRYAB crystallin, alpha B
DUSP1 dual specificity phosphatase 1
FBN1 fibrillin 1
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
JADE2 jade family PHD finger 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEFH neurofilament, heavy polypeptide
NNMT nicotinamide N-methyltransferase
PBK PDZ binding kinase
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPP1R13B protein phosphatase 1, regulatory subunit 13B
XIST X inactive specific transcript (non-protein coding)