BRD-K04887706_AKT-inhibitor-1-2_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACB acetyl-CoA carboxylase beta
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
C5 complement component 5
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DSP desmoplakin
EFNA1 ephrin-A1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERLIN2 ER lipid raft associated 2
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FST follistatin
FZD7 frizzled class receptor 7
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GSDMB gasdermin B
H1FX H1 histone family, member X
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGF1R insulin-like growth factor 1 receptor
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
KLF4 Kruppel-like factor 4 (gut)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMCH1 LIM and calponin homology domains 1
LXN latexin
LYZ lysozyme
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MYO6 myosin VI
OSBPL1A oxysterol binding protein-like 1A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PHACTR2 phosphatase and actin regulator 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PPAP2B phosphatidic acid phosphatase type 2B
PTK2 protein tyrosine kinase 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP4 retinol binding protein 4, plasma
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SYNE2 spectrin repeat containing, nuclear envelope 2
TBX2 T-box 2
TCTN1 tectonic family member 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
WDR19 WD repeat domain 19
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASRGL1 asparaginase like 1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CPM carboxypeptidase M
DUSP7 dual specificity phosphatase 7
EMX2 empty spiracles homeobox 2
EREG epiregulin
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
FTO fat mass and obesity associated
GLIPR1 GLI pathogenesis-related 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HES1 hes family bHLH transcription factor 1
IL1B interleukin 1, beta
JUN jun proto-oncogene
LAPTM4B lysosomal protein transmembrane 4 beta
LPXN leupaxin
MAGEB2 melanoma antigen family B2
MAMLD1 mastermind-like domain containing 1
MAP7 microtubule-associated protein 7
MEIS2 Meis homeobox 2
MYRF myelin regulatory factor
NOV nephroblastoma overexpressed
PARP2 poly (ADP-ribose) polymerase 2
PPME1 protein phosphatase methylesterase 1
PRPF4 pre-mRNA processing factor 4
RAD51C RAD51 paralog C
RBKS ribokinase
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB1 SATB homeobox 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TPD52 tumor protein D52
WT1 Wilms tumor 1