BRD-K04887706_AKT-inhibitor-1-2_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD52 CD52 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC5 chloride intracellular channel 5
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COCH cochlin
COL10A1 collagen, type X, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CTSB cathepsin B
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FBLN1 fibulin 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BD histone cluster 1, H2bd
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IGFBP7 insulin-like growth factor binding protein 7
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT19 keratin 19, type I
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LEPROT leptin receptor overlapping transcript
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LXN latexin
MAGED2 melanoma antigen family D2
MCOLN1 mucolipin 1
MGST3 microsomal glutathione S-transferase 3
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MYO1D myosin ID
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NPR3 natriuretic peptide receptor 3
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
OPTN optineurin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PNPLA3 patatin-like phospholipase domain containing 3
PROM1 prominin 1
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
RAB5B RAB5B, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP2A RAP2A, member of RAS oncogene family
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERF2 small EDRK-rich factor 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFXN3 sideroflexin 3
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPRR1B small proline-rich protein 1B
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STXBP1 syntaxin binding protein 1
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ASF1B anti-silencing function 1B histone chaperone
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CIAPIN1 cytokine induced apoptosis inhibitor 1
COL3A1 collagen, type III, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL8 chemokine (C-X-C motif) ligand 8
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EMX2 empty spiracles homeobox 2
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
GYG1 glycogenin 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA14 heat shock 70kDa protein 14
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LBR lamin B receptor
LDHB lactate dehydrogenase B
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MECOM MDS1 and EVI1 complex locus
MMP7 matrix metallopeptidase 7
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PDLIM3 PDZ and LIM domain 3
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTTG1 pituitary tumor-transforming 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SMAD1 SMAD family member 1
SMC2 structural maintenance of chromosomes 2
SRGN serglycin
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
WNT5A wingless-type MMTV integration site family, member 5A
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein