BRD-K04887706_AKT-inhibitor-1-2_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AHNAK2 AHNAK nucleoprotein 2
ARL4C ADP-ribosylation factor-like 4C
C14ORF1 chromosome 14 open reading frame 1
CCNI cyclin I
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSF1R colony stimulating factor 1 receptor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FRY furry homolog (Drosophila)
HMGB3 high mobility group box 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MPDZ multiple PDZ domain protein
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NBPF10 neuroblastoma breakpoint family, member 10
NOTCH1 notch 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OPN3 opsin 3
PCDH17 protocadherin 17
RNASE6 ribonuclease, RNase A family, k6
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SQLE squalene epoxidase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAB1 stabilin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TYROBP TYRO protein tyrosine kinase binding protein
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADM adrenomedullin
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CCL2 chemokine (C-C motif) ligand 2
CD200 CD200 molecule
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L2 chitinase 3-like 2
CRISP3 cysteine-rich secretory protein 3
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGF epidermal growth factor
ELF5 E74-like factor 5 (ets domain transcription factor)
EPHA3 EPH receptor A3
FKBP14 FK506 binding protein 14, 22 kDa
FLNB filamin B, beta
FNDC3B fibronectin type III domain containing 3B
GBP1 guanylate binding protein 1, interferon-inducible
GSPT1 G1 to S phase transition 1
GSTM3 glutathione S-transferase mu 3 (brain)
HAPLN1 hyaluronan and proteoglycan link protein 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BK histone cluster 1, H2bk
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
ITGAV integrin, alpha V
KRT7 keratin 7, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LPL lipoprotein lipase
LY75 lymphocyte antigen 75
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
ORM1 orosomucoid 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRDX4 peroxiredoxin 4
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SELL selectin L
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SRPRB signal recognition particle receptor, B subunit
STC2 stanniocalcin 2
TFRC transferrin receptor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPM4 tropomyosin 4
TSPAN8 tetraspanin 8
ZDHHC11 zinc finger, DHHC-type containing 11