BRD-K04887706_AKT-inhibitor-1-2_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AHNAK2 AHNAK nucleoprotein 2
ARMCX1 armadillo repeat containing, X-linked 1
BCL2 B-cell CLL/lymphoma 2
BGN biglycan
C14ORF132 chromosome 14 open reading frame 132
CCNG2 cyclin G2
CFB complement factor B
CLU clusterin
CPD carboxypeptidase D
CREB1 cAMP responsive element binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CSF1R colony stimulating factor 1 receptor
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GAGE3 G antigen 3
GLUL glutamate-ammonia ligase
HIST1H2BD histone cluster 1, H2bd
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LDLR low density lipoprotein receptor
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
PAIP1 poly(A) binding protein interacting protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RHOT1 ras homolog family member T1
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TM7SF2 transmembrane 7 superfamily member 2
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CALML5 calmodulin-like 5
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDKN2A cyclin-dependent kinase inhibitor 2A
CRYAB crystallin, alpha B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
EIF3I eukaryotic translation initiation factor 3, subunit I
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP7 fatty acid binding protein 7, brain
FAM171A1 family with sequence similarity 171, member A1
FAM57A family with sequence similarity 57, member A
FAT1 FAT atypical cadherin 1
GATA3 GATA binding protein 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
HN1 hematological and neurological expressed 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
JUN jun proto-oncogene
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KYNU kynureninase
LOXL2 lysyl oxidase-like 2
MCM7 minichromosome maintenance complex component 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MRPS7 mitochondrial ribosomal protein S7
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
OLFM4 olfactomedin 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFKP phosphofructokinase, platelet
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PRMT1 protein arginine methyltransferase 1
PTRF polymerase I and transcript release factor
RANBP1 RAN binding protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RPL37A ribosomal protein L37a
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
TAGLN transgelin
TFRC transferrin receptor
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa