BRD-K04853698_LDN-193189_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K04853698_LDN-193189_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
CCL19 chemokine (C-C motif) ligand 19
CCND2 cyclin D2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRIP2 cysteine-rich protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
DCN decorin
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
KRT14 keratin 14, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
SGPP1 sphingosine-1-phosphate phosphatase 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TPPP3 tubulin polymerization-promoting protein family member 3
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BMP2 bone morphogenetic protein 2
CDA cytidine deaminase
CES1 carboxylesterase 1
CNN3 calponin 3, acidic
CPM carboxypeptidase M
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
CYTH1 cytohesin 1
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
GPX3 glutathione peroxidase 3
HSPB1 heat shock 27kDa protein 1
IER3 immediate early response 3
IL6 interleukin 6
INHBB inhibin, beta B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
MGLL monoglyceride lipase
MSX1 msh homeobox 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRIP1 nuclear receptor interacting protein 1
PNMA2 paraneoplastic Ma antigen 2
PRKCD protein kinase C, delta
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SPARCL1 SPARC-like 1 (hevin)
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TKT transketolase
TREM1 triggering receptor expressed on myeloid cells 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VSIG4 V-set and immunoglobulin domain containing 4
ZBTB38 zinc finger and BTB domain containing 38