BRD-K04853698_-666_SNUC4_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K04853698_-666_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AKAP8L A kinase (PRKA) anchor protein 8-like
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BAD BCL2-associated agonist of cell death
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD9 CD9 molecule
CHIT1 chitinase 1 (chitotriosidase)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL14A1 collagen, type XIV, alpha 1
CPE carboxypeptidase E
CPM carboxypeptidase M
CXCL2 chemokine (C-X-C motif) ligand 2
CYTH1 cytohesin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EIF5A eukaryotic translation initiation factor 5A
ELN elastin
EMP1 epithelial membrane protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EZR ezrin
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL6 interleukin 6
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD12 potassium channel tetramerization domain containing 12
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KYNU kynureninase
LAMC2 laminin, gamma 2
LAMP5 lysosomal-associated membrane protein family, member 5
LARP6 La ribonucleoprotein domain family, member 6
MGP matrix Gla protein
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MTMR9 myotubularin related protein 9
MX1 MX dynamin-like GTPase 1
MYH11 myosin, heavy chain 11, smooth muscle
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PEG10 paternally expressed 10
PLIN1 perilipin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PRNP prion protein
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RDX radixin
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RNF167 ring finger protein 167
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TMSB15A thymosin beta 15a
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCHE butyrylcholinesterase
CD81 CD81 molecule
CD99 CD99 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
COL11A1 collagen, type XI, alpha 1
CST6 cystatin E/M
CTSB cathepsin B
ENDOD1 endonuclease domain containing 1
EPN2 epsin 2
FABP7 fatty acid binding protein 7, brain
GDI2 GDP dissociation inhibitor 2
GLRX glutaredoxin (thioltransferase)
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRN granulin
GSS glutathione synthetase
HAL histidine ammonia-lyase
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IGHM immunoglobulin heavy constant mu
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL3 methyltransferase like 3
MFAP3L microfibrillar-associated protein 3-like
MRPL19 mitochondrial ribosomal protein L19
NREP neuronal regeneration related protein
OXA1L oxidase (cytochrome c) assembly 1-like
OXTR oxytocin receptor
PARP2 poly (ADP-ribose) polymerase 2
PDZK1 PDZ domain containing 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK1 polo-like kinase 1
PRAME preferentially expressed antigen in melanoma
PROS1 protein S (alpha)
PRSS23 protease, serine, 23
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTER phosphotriesterase related
QPRT quinolinate phosphoribosyltransferase
SCAND1 SCAN domain containing 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SPATS2L spermatogenesis associated, serine-rich 2-like
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM109 transmembrane protein 109
TUBB tubulin, beta class I
TXNL4B thioredoxin-like 4B
TYMS thymidylate synthetase
VGLL4 vestigial-like family member 4
WT1 Wilms tumor 1
ZMAT3 zinc finger, matrin-type 3