BRD-K04853698_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

339 genes differentially expressed following the BRD-K04853698_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
AKAP13 A kinase (PRKA) anchor protein 13
APOD apolipoprotein D
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL3 B-cell CLL/lymphoma 3
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C3ORF52 chromosome 3 open reading frame 52
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CD9 CD9 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL6A3 collagen, type VI, alpha 3
COL9A2 collagen, type IX, alpha 2
CREM cAMP responsive element modulator
CSF1 colony stimulating factor 1 (macrophage)
CTGF connective tissue growth factor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR24 24-dehydrocholesterol reductase
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENAH enabled homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ERBB4 erb-b2 receptor tyrosine kinase 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FBLN1 fibulin 1
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC15 leucine rich repeat containing 15
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCL1 myeloid cell leukemia 1
MFAP2 microfibrillar-associated protein 2
MIR22HG MIR22 host gene
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
NUPL1 nucleoporin like 1
PER1 period circadian clock 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS21 protease, serine, 21 (testisin)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RND1 Rho family GTPase 1
RRAGC Ras-related GTP binding C
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD7 SMAD family member 7
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SST somatostatin
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TICAM1 toll-like receptor adaptor molecule 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TMPRSS3 transmembrane protease, serine 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52 tumor protein D52
TRIB1 tribbles pseudokinase 1
TRIM36 tripartite motif containing 36
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANPEP alanyl (membrane) aminopeptidase
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASXL2 additional sex combs like transcriptional regulator 2
ATMIN ATM interactor
B3GNT1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CBX3 chromobox homolog 3
CBX5 chromobox homolog 5
CCNA2 cyclin A2
CCNF cyclin F
CCNG1 cyclin G1
CDC20 cell division cycle 20
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CRTAP cartilage associated protein
CRYL1 crystallin, lambda 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDB2 damage-specific DNA binding protein 2, 48kDa
DEFB1 defensin, beta 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPYSL2 dihydropyrimidinase-like 2
EFCAB11 EF-hand calcium binding domain 11
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM111A family with sequence similarity 111, member A
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1L hematological and neurological expressed 1-like
HOXC6 homeobox C6
HRSP12 heat-responsive protein 12
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IPO5 importin 5
KANK2 KN motif and ankyrin repeat domains 2
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LIMS1 LIM and senescent cell antigen-like domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPLA1 lysophospholipase I
MCM6 minichromosome maintenance complex component 6
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MKI67 marker of proliferation Ki-67
MRPL19 mitochondrial ribosomal protein L19
MSH2 mutS homolog 2
MTDH metadherin
NDC80 NDC80 kinetochore complex component
NES nestin
NMI N-myc (and STAT) interactor
NOSIP nitric oxide synthase interacting protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PIR pirin (iron-binding nuclear protein)
PKP4 plakophilin 4
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSRC1 proline/serine-rich coiled-coil 1
PXDN peroxidasin
RAB31 RAB31, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RAP2A RAP2A, member of RAS oncogene family
RBM47 RNA binding motif protein 47
RGS5 regulator of G-protein signaling 5
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RRM1 ribonucleotide reductase M1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC2 structural maintenance of chromosomes 2
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
STAMBP STAM binding protein
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D16 TBC1 domain family, member 16
TDP1 tyrosyl-DNA phosphodiesterase 1
TFDP1 transcription factor Dp-1
TM9SF2 transmembrane 9 superfamily member 2
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAK2 trafficking protein, kinesin binding 2
TRIM14 tripartite motif containing 14
TTK TTK protein kinase
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
VCAN versican
VRK1 vaccinia related kinase 1
XPOT exportin, tRNA
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZC3H13 zinc finger CCCH-type containing 13
ZMYM3 zinc finger, MYM-type 3
ZNF106 zinc finger protein 106
ZNF185 zinc finger protein 185 (LIM domain)