BRD-K04853698_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

324 genes differentially expressed following the BRD-K04853698_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM17 ADAM metallopeptidase domain 17
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C3ORF52 chromosome 3 open reading frame 52
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
COL14A1 collagen, type XIV, alpha 1
COMP cartilage oligomeric matrix protein
CRIP1 cysteine-rich protein 1 (intestinal)
CRY1 cryptochrome circadian clock 1
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFHD2 EF-hand domain family, member D2
EFNA1 ephrin-A1
EGR1 early growth response 1
EHD1 EH-domain containing 1
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2B general transcription factor IIB
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HRH1 histamine receptor H1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
IL32 interleukin 32
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFRL platelet-derived growth factor receptor-like
PER1 period circadian clock 1
PER2 period circadian clock 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK3 polo-like kinase 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM2 PR domain containing 2, with ZNF domain
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RLF rearranged L-myc fusion
RND1 Rho family GTPase 1
RNF167 ring finger protein 167
RNF19B ring finger protein 19B
RRAD Ras-related associated with diabetes
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SPEN spen family transcriptional repressor
SRRM2 serine/arginine repetitive matrix 2
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEX10 testis expressed 10
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TOB2 transducer of ERBB2, 2
TOP1 topoisomerase (DNA) I
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
WTAP Wilms tumor 1 associated protein
ZBTB43 zinc finger and BTB domain containing 43
ZC3H12A zinc finger CCCH-type containing 12A
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
AURKA aurora kinase A
B3GNT1
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CCNA2 cyclin A2
CCNF cyclin F
CCNG1 cyclin G1
CDKN3 cyclin-dependent kinase inhibitor 3
CKAP2 cytoskeleton associated protein 2
CLIC4 chloride intracellular channel 4
CPNE3 copine III
CXCL12 chemokine (C-X-C motif) ligand 12
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERBB3 erb-b2 receptor tyrosine kinase 3
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPI glucose-6-phosphate isomerase
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1L hematological and neurological expressed 1-like
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IPO5 importin 5
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KPNB1 karyopherin (importin) beta 1
KRCC1 lysine-rich coiled-coil 1
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGED1 melanoma antigen family D1
MRPL19 mitochondrial ribosomal protein L19
MTIF2 mitochondrial translational initiation factor 2
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NES nestin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NQO2 NAD(P)H dehydrogenase, quinone 2
OIP5 Opa interacting protein 5
P4HB prolyl 4-hydroxylase, beta polypeptide
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PKP4 plakophilin 4
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PPA2 pyrophosphatase (inorganic) 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSPH phosphoserine phosphatase
PXDN peroxidasin
QARS glutaminyl-tRNA synthetase
RACGAP1 Rac GTPase activating protein 1
RAD21 RAD21 homolog (S. pombe)
RBPMS RNA binding protein with multiple splicing
RPA1 replication protein A1, 70kDa
SAMM50 SAMM50 sorting and assembly machinery component
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SMC2 structural maintenance of chromosomes 2
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SSR1 signal sequence receptor, alpha
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D16 TBC1 domain family, member 16
TM9SF2 transmembrane 9 superfamily member 2
TMED2 transmembrane emp24 domain trafficking protein 2
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TWF1 twinfilin actin binding protein 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC13B unc-13 homolog B (C. elegans)
WDR1 WD repeat domain 1
XPOT exportin, tRNA
YME1L1 YME1-like 1 ATPase