BRD-K04853698_-666_H1299_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K04853698_-666_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
ALDOB aldolase B, fructose-bisphosphate
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CALML4 calmodulin-like 4
CCNL1 cyclin L1
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDHR5 cadherin-related family member 5
CLCA1 chloride channel accessory 1
COL15A1 collagen, type XV, alpha 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DEFA5 defensin, alpha 5, Paneth cell-specific
EDNRB endothelin receptor type B
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAIM Fas apoptotic inhibitory molecule
FGFR2 fibroblast growth factor receptor 2
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HES1 hes family bHLH transcription factor 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KTN1 kinectin 1 (kinesin receptor)
LMO3 LIM domain only 3 (rhombotin-like 2)
MT1E metallothionein 1E
MUC2 mucin 2, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NACA nascent polypeptide-associated complex alpha subunit
NCAM1 neural cell adhesion molecule 1
NCAPD2 non-SMC condensin I complex, subunit D2
NEB nebulin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PON3 paraoxonase 3
POU4F1 POU class 4 homeobox 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SEC62 SEC62 homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM176B transmembrane protein 176B
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
TSPAN7 tetraspanin 7
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AK1 adenylate kinase 1
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ANXA6 annexin A6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASCC3 activating signal cointegrator 1 complex subunit 3
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
BPGM 2,3-bisphosphoglycerate mutase
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
C2CD2 C2 calcium-dependent domain containing 2
CBR3 carbonyl reductase 3
CBX6 chromobox homolog 6
CCDC92 coiled-coil domain containing 92
CCNA2 cyclin A2
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COTL1 coactosin-like F-actin binding protein 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FLNA filamin A, alpha
FSTL1 follistatin-like 1
GPI glucose-6-phosphate isomerase
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IFITM2 interferon induced transmembrane protein 2
IGFBP6 insulin-like growth factor binding protein 6
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM5D lysine (K)-specific demethylase 5D
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MRPS30 mitochondrial ribosomal protein S30
NDRG2 NDRG family member 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
OXTR oxytocin receptor
PARP2 poly (ADP-ribose) polymerase 2
PCYOX1L prenylcysteine oxidase 1 like
PENK proenkephalin
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PPA1 pyrophosphatase (inorganic) 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRKCZ protein kinase C, zeta
PSCA prostate stem cell antigen
PWP1 PWP1 homolog (S. cerevisiae)
QARS glutaminyl-tRNA synthetase
QPRT quinolinate phosphoribosyltransferase
RHOBTB3 Rho-related BTB domain containing 3
RPIA ribose 5-phosphate isomerase A
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RWDD2B RWD domain containing 2B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SORD sorbitol dehydrogenase
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STEAP3 STEAP family member 3, metalloreductase
STOM stomatin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDP1 tyrosyl-DNA phosphodiesterase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM9SF2 transmembrane 9 superfamily member 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TPM1 tropomyosin 1 (alpha)
TSPO translocator protein (18kDa)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UROS uroporphyrinogen III synthase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDTC1 WD and tetratricopeptide repeats 1
ZCCHC24 zinc finger, CCHC domain containing 24