BRD-K04695623_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K04695623_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCPG1 cell cycle progression 1
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EDNRB endothelin receptor type B
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GTPBP2 GTP binding protein 2
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MOCOS molybdenum cofactor sulfurase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PRDX2 peroxiredoxin 2
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RHOBTB3 Rho-related BTB domain containing 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SST somatostatin
STC2 stanniocalcin 2
STMN2 stathmin 2
THBS2 thrombospondin 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VLDLR very low density lipoprotein receptor
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ATF5 activating transcription factor 5
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CAST calpastatin
CCND1 cyclin D1
CDC25A cell division cycle 25A
COL6A1 collagen, type VI, alpha 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
EHD1 EH-domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LBH limb bud and heart development
LRP4 low density lipoprotein receptor-related protein 4
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFAP2 microfibrillar-associated protein 2
MFSD10 major facilitator superfamily domain containing 10
MT1E metallothionein 1E
MXRA7 matrix-remodelling associated 7
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PWP1 PWP1 homolog (S. cerevisiae)
SCML1 sex comb on midleg-like 1 (Drosophila)
SCRN1 secernin 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
TACSTD2 tumor-associated calcium signal transducer 2
TSPAN5 tetraspanin 5
UBE2S ubiquitin-conjugating enzyme E2S
ZDHHC6 zinc finger, DHHC-type containing 6