BRD-K04695623_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K04695623_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BTG1 B-cell translocation gene 1, anti-proliferative
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDIT4 DNA-damage-inducible transcript 4
DPT dermatopontin
DUSP4 dual specificity phosphatase 4
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FXYD5 FXYD domain containing ion transport regulator 5
GAGE3 G antigen 3
GC group-specific component (vitamin D binding protein)
GLUL glutamate-ammonia ligase
HIST2H2BE histone cluster 2, H2be
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KRT19 keratin 19, type I
LPAR6 lysophosphatidic acid receptor 6
MAOB monoamine oxidase B
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PHGDH phosphoglycerate dehydrogenase
RAP1GAP RAP1 GTPase activating protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SPON2 spondin 2, extracellular matrix protein
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATAD2 ATPase family, AAA domain containing 2
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EGR3 early growth response 3
FANCI Fanconi anemia, complementation group I
GJA1 gap junction protein, alpha 1, 43kDa
GRB14 growth factor receptor-bound protein 14
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HSPA4L heat shock 70kDa protein 4-like
IRF8 interferon regulatory factor 8
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MSH6 mutS homolog 6
NCAPG2 non-SMC condensin II complex, subunit G2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFH neurofilament, heavy polypeptide
NPY1R neuropeptide Y receptor Y1
NUP62 nucleoporin 62kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAD54B RAD54 homolog B (S. cerevisiae)
RBM47 RNA binding motif protein 47
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
SC5D sterol-C5-desaturase
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMS spermine synthase
SPAG1 sperm associated antigen 1
SPDL1 spindle apparatus coiled-coil protein 1
SQLE squalene epoxidase
TFF1 trefoil factor 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPYL5 TSPY-like 5
TTK TTK protein kinase
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TYRP1 tyrosinase-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
XBP1 X-box binding protein 1