BRD-K04548931_EPIRUBICIN HYDROCHLORIDE_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

293 genes differentially expressed following the BRD-K04548931_EPIRUBICIN HYDROCHLORIDE_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ACPP acid phosphatase, prostate
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AOC3 amine oxidase, copper containing 3
AQP1 aquaporin 1 (Colton blood group)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BLNK B-cell linker
BTG2 BTG family, member 2
C7 complement component 7
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CD93 CD93 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFD complement factor D (adipsin)
CHGB chromogranin B
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DMXL2 Dmx-like 2
DPT dermatopontin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR3 fibroblast growth factor receptor 3
FGR FGR proto-oncogene, Src family tyrosine kinase
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXF1 forkhead box F1
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPC4 glypican 4
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IDS iduronate 2-sulfatase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INA internexin neuronal intermediate filament protein, alpha
IRF6 interferon regulatory factor 6
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA1462 KIAA1462
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PARM1 prostate androgen-regulated mucin-like protein 1
PBX1 pre-B-cell leukemia homeobox 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG3 paternally expressed 3
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PRR15L proline rich 15-like
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNF167 ring finger protein 167
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPARCL1 SPARC-like 1 (hevin)
SST somatostatin
STAR steroidogenic acute regulatory protein
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM35 transmembrane protein 35
TMEM47 transmembrane protein 47
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN31 tetraspanin 31
TYROBP TYRO protein tyrosine kinase binding protein
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR7 WD repeat domain 7
WFDC1 WAP four-disulfide core domain 1
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ARMCX6 armadillo repeat containing, X-linked 6
ARPC5L actin related protein 2/3 complex, subunit 5-like
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CBFB core-binding factor, beta subunit
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ECI2 enoyl-CoA delta isomerase 2
EGFR epidermal growth factor receptor
EIF4A3 eukaryotic translation initiation factor 4A3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GRB10 growth factor receptor-bound protein 10
GRWD1 glutamate-rich WD repeat containing 1
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KIF14 kinesin family member 14
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OXTR oxytocin receptor
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RBM14 RNA binding motif protein 14
RBM7 RNA binding motif protein 7
RCAN1 regulator of calcineurin 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC24A SEC24 family member A
SETD5 SET domain containing 5
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STXBP1 syntaxin binding protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBP TATA box binding protein
TCTA T-cell leukemia translocation altered
TEX30 testis expressed 30
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMEM243 transmembrane protein 243, mitochondrial
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB38 zinc finger and BTB domain containing 38