BRD-K04548931_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K04548931_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA1 annexin A1
ANXA4 annexin A4
APLP2 amyloid beta (A4) precursor-like protein 2
BACE2 beta-site APP-cleaving enzyme 2
BLNK B-cell linker
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD72 CD72 molecule
CEP70 centrosomal protein 70kDa
CHN1 chimerin 1
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
COMP cartilage oligomeric matrix protein
CREM cAMP responsive element modulator
CXCL8 chemokine (C-X-C motif) ligand 8
DAAM2 dishevelled associated activator of morphogenesis 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FST follistatin
GABARAPL1 GABA(A) receptor-associated protein like 1
GAGE3 G antigen 3
GLUD2 glutamate dehydrogenase 2
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
IL1R1 interleukin 1 receptor, type I
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MEIS1 Meis homeobox 1
NDRG2 NDRG family member 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PLXNB1 plexin B1
PPAP2A phosphatidic acid phosphatase type 2A
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
S100A4 S100 calcium binding protein A4
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TSPAN7 tetraspanin 7
VGLL1 vestigial-like family member 1
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ARF6 ADP-ribosylation factor 6
ARMCX3 armadillo repeat containing, X-linked 3
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BHLHE41 basic helix-loop-helix family, member e41
CA12 carbonic anhydrase XII
CCDC59 coiled-coil domain containing 59
CCNA2 cyclin A2
CCNB2 cyclin B2
CD200 CD200 molecule
CDC20 cell division cycle 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHERP calcium homeostasis endoplasmic reticulum protein
CKS2 CDC28 protein kinase regulatory subunit 2
CSK c-src tyrosine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM134B family with sequence similarity 134, member B
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H4C histone cluster 1, H4c
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IER2 immediate early response 2
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
JCHAIN joining chain of multimeric IgA and IgM
KAT6A K(lysine) acetyltransferase 6A
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KRT14 keratin 14, type I
KRT7 keratin 7, type II
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MED13 mediator complex subunit 13
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLPH melanophilin
MRPS35 mitochondrial ribosomal protein S35
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NSG1 neuron specific gene family member 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PADI2 peptidyl arginine deiminase, type II
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCD protein kinase C, delta
PRPF4B pre-mRNA processing factor 4B
PUF60 poly-U binding splicing factor 60KDa
RPL36AL ribosomal protein L36a-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCGB2A2 secretoglobin, family 2A, member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBP TATA box binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM176B transmembrane protein 176B
TNPO1 transportin 1
TOR1A torsin family 1, member A (torsin A)
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
XBP1 X-box binding protein 1
ZNF146 zinc finger protein 146