BRD-K04548931_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

286 genes differentially expressed following the BRD-K04548931_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ARHGAP44 Rho GTPase activating protein 44
BLVRB biliverdin reductase B
BSG basigin (Ok blood group)
CA1 carbonic anhydrase I
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD200 CD200 molecule
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CECR1 cat eye syndrome chromosome region, candidate 1
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL10 chemokine (C-X-C motif) ligand 10
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCHS1 dachsous cadherin-related 1
DCN decorin
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
FGG fibrinogen gamma chain
FILIP1L filamin A interacting protein 1-like
FOXF1 forkhead box F1
GJA1 gap junction protein, alpha 1, 43kDa
HBB hemoglobin, beta
HBD hemoglobin, delta
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LDOC1 leucine zipper, down-regulated in cancer 1
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MAOA monoamine oxidase A
MATN2 matrilin 2
MMP9 matrix metallopeptidase 9
NMU neuromedin U
NREP neuronal regeneration related protein
NSG1 neuron specific gene family member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG3 paternally expressed 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE6 ribonuclease, RNase A family, k6
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SH3BGRL SH3 domain binding glutamate-rich protein like
SOX11 SRY (sex determining region Y)-box 11
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TMSB15B thymosin beta 15B
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASXL2 additional sex combs like transcriptional regulator 2
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EHD1 EH-domain containing 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4B eukaryotic translation initiation factor 4B
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV5 ets variant 5
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
FAM208B family with sequence similarity 208, member B
FAM46A family with sequence similarity 46, member A
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXJ3 forkhead box J3
FSCN1 fascin actin-bundling protein 1
GEMIN4 gem (nuclear organelle) associated protein 4
GRWD1 glutamate-rich WD repeat containing 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IL6R interleukin 6 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LRIF1 ligand dependent nuclear receptor interacting factor 1
LSG1 large 60S subunit nuclear export GTPase 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MTF2 metal response element binding transcription factor 2
MXRA7 matrix-remodelling associated 7
MYLIP myosin regulatory light chain interacting protein
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTX3 pentraxin 3, long
RAB14 RAB14, member RAS oncogene family
RAD51C RAD51 paralog C
RANBP6 RAN binding protein 6
RBM15 RNA binding motif protein 15
RPL27A ribosomal protein L27a
RPP25 ribonuclease P/MRP 25kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RRAGD Ras-related GTP binding D
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SET SET nuclear proto-oncogene
SETD5 SET domain containing 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SNX11 sorting nexin 11
SOCS5 suppressor of cytokine signaling 5
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF2 serine/arginine-rich splicing factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM243 transmembrane protein 243, mitochondrial
TNC tenascin C
TOB1 transducer of ERBB2, 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEZF1 vascular endothelial zinc finger 1
VGLL4 vestigial-like family member 4
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2
ZNF281 zinc finger protein 281