BRD-K04546108_JAK3 Inhibitor VI_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

243 genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOA1 apolipoprotein A-I
APOD apolipoprotein D
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BPI bactericidal/permeability-increasing protein
BTG3 BTG family, member 3
C3 complement component 3
CA2 carbonic anhydrase II
CAMP cathelicidin antimicrobial peptide
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC85B coiled-coil domain containing 85B
CCL8 chemokine (C-C motif) ligand 8
CD200 CD200 molecule
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CETN2 centrin, EF-hand protein, 2
CFD complement factor D (adipsin)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC5A C-type lectin domain family 5, member A
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DPT dermatopontin
DST dystonin
EDN1 endothelin 1
EGR2 early growth response 2
EGR3 early growth response 3
ELOVL4 ELOVL fatty acid elongase 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM198B family with sequence similarity 198, member B
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFT57 intraflagellar transport 57
IGF1 insulin-like growth factor 1 (somatomedin C)
IRF8 interferon regulatory factor 8
IVNS1ABP influenza virus NS1A binding protein
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAMP2 lysosomal-associated membrane protein 2
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MARCKSL1 MARCKS-like 1
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MSLN mesothelin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NSG1 neuron specific gene family member 1
NXN nucleoredoxin
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
PPAP2B phosphatidic acid phosphatase type 2B
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORT1 sortilin 1
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSPN sarcospan
STK17B serine/threonine kinase 17b
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADRB2 adrenoceptor beta 2, surface
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
AURKB aurora kinase B
BASP1 brain abundant, membrane attached signal protein 1
BLM Bloom syndrome, RecQ helicase-like
BORA bora, aurora kinase A activator
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
CAB39 calcium binding protein 39
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD58 CD58 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHMP6 charged multivesicular body protein 6
CHN2 chimerin 2
COL4A2 collagen, type IV, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
ERBB3 erb-b2 receptor tyrosine kinase 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM111A family with sequence similarity 111, member A
FAM216A family with sequence similarity 216, member A
FGF13 fibroblast growth factor 13
FOXD1 forkhead box D1
GOLGA8A golgin A8 family, member A
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC10 homeobox C10
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KIAA1033 KIAA1033
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KRT18 keratin 18, type I
LINC00341 long intergenic non-protein coding RNA 341
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MED13 mediator complex subunit 13
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTDH metadherin
NAV2 neuron navigator 2
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NID2 nidogen 2 (osteonidogen)
NMI N-myc (and STAT) interactor
NMT1 N-myristoyltransferase 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
OLFML2B olfactomedin-like 2B
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRC1 protein regulator of cytokinesis 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTGES prostaglandin E synthase
PTMA prothymosin, alpha
PURA purine-rich element binding protein A
PXDN peroxidasin
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RRM1 ribonucleotide reductase M1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D31 TBC1 domain family, member 31
TDP1 tyrosyl-DNA phosphodiesterase 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TLK1 tousled-like kinase 1
TMEM194A transmembrane protein 194A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRAK2 trafficking protein, kinesin binding 2
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBGCP3 tubulin, gamma complex associated protein 3
USP22 ubiquitin specific peptidase 22
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
WFS1 Wolfram syndrome 1 (wolframin)
ZC3H4 zinc finger CCCH-type containing 4
ZHX2 zinc fingers and homeoboxes 2
ZNF451 zinc finger protein 451
ZNF638 zinc finger protein 638