BRD-K04546108_JAK3 Inhibitor VI_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APLP2 amyloid beta (A4) precursor-like protein 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAMBI BMP and activin membrane-bound inhibitor
BIRC3 baculoviral IAP repeat containing 3
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CKM creatine kinase, muscle
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
EFNB2 ephrin-B2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL4 ELOVL fatty acid elongase 4
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GSN gelsolin
HIPK1 homeodomain interacting protein kinase 1
HIST2H2BE histone cluster 2, H2be
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
JAG1 jagged 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
MAOB monoamine oxidase B
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
OPTN optineurin
PAM peptidylglycine alpha-amidating monooxygenase
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLD3 phospholipase D family, member 3
PPAP2B phosphatidic acid phosphatase type 2B
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGCC regulator of cell cycle
S100A10 S100 calcium binding protein A10
SCG2 secretogranin II
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SEPW1 selenoprotein W, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SH3BGR SH3 domain binding glutamate-rich protein
SKP1 S-phase kinase-associated protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
STC2 stanniocalcin 2
TAGLN2 transgelin 2
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TNNC2 troponin C type 2 (fast)
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
ZFP36 ZFP36 ring finger protein
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
COG2 component of oligomeric golgi complex 2
COMT catechol-O-methyltransferase
CXCL12 chemokine (C-X-C motif) ligand 12
DEPTOR DEP domain containing MTOR-interacting protein
DST dystonin
ETV5 ets variant 5
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GOLGA8A golgin A8 family, member A
HSPA2 heat shock 70kDa protein 2
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LEFTY1 left-right determination factor 1
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LPPR1 lipid phosphate phosphatase-related protein type 1
LRRC16A leucine rich repeat containing 16A
MKI67 marker of proliferation Ki-67
MT1X metallothionein 1X
MTA1 metastasis associated 1
NID2 nidogen 2 (osteonidogen)
NUSAP1 nucleolar and spindle associated protein 1
PDS5B PDS5 cohesin associated factor B
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PROM1 prominin 1
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCYL3 SCY1-like 3 (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SH3BP4 SH3-domain binding protein 4
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMC4 structural maintenance of chromosomes 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
UBE3C ubiquitin protein ligase E3C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
ZC3H13 zinc finger CCCH-type containing 13
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMYM2 zinc finger, MYM-type 2
ZNF451 zinc finger protein 451
ZNF638 zinc finger protein 638