BRD-K04546108_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

282 genes differentially expressed following the BRD-K04546108_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX4 brain expressed, X-linked 4
BTG3 BTG family, member 3
C3 complement component 3
CALML5 calmodulin-like 5
CD1D CD1d molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
COMP cartilage oligomeric matrix protein
CST3 cystatin C
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DPT dermatopontin
DPYSL2 dihydropyrimidinase-like 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELOVL4 ELOVL fatty acid elongase 4
ENO2 enolase 2 (gamma, neuronal)
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM171A1 family with sequence similarity 171, member A1
FASTKD5 FAST kinase domains 5
FEM1C fem-1 homolog c (C. elegans)
FLG filaggrin
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GJA1 gap junction protein, alpha 1, 43kDa
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IRF8 interferon regulatory factor 8
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
KIAA0907 KIAA0907
KLF10 Kruppel-like factor 10
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCL1 myeloid cell leukemia 1
MECOM MDS1 and EVI1 complex locus
MFAP2 microfibrillar-associated protein 2
MMP9 matrix metallopeptidase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OGDHL oxoglutarate dehydrogenase-like
PAM peptidylglycine alpha-amidating monooxygenase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PSAP prosaposin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBP1 retinol binding protein 1, cellular
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF11 ring finger protein 11
SCG2 secretogranin II
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35F2 solute carrier family 35, member F2
SORT1 sortilin 1
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STK17B serine/threonine kinase 17b
SYT1 synaptotagmin I
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOB1 transducer of ERBB2, 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WASF3 WAS protein family, member 3

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRG6 adhesion G protein-coupled receptor G6
AKAP10 A kinase (PRKA) anchor protein 10
ALOX5 arachidonate 5-lipoxygenase
ANKRD17 ankyrin repeat domain 17
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
AVL9 AVL9 homolog (S. cerevisiase)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRD8 bromodomain containing 8
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
CALR calreticulin
CASP8AP2 caspase 8 associated protein 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD58 CD58 molecule
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CEP68 centrosomal protein 68kDa
CHD9 chromodomain helicase DNA binding protein 9
CNOT7 CCR4-NOT transcription complex, subunit 7
DEPDC1 DEP domain containing 1
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
EMP2 epithelial membrane protein 2
ERGIC2 ERGIC and golgi 2
ERI2 ERI1 exoribonuclease family member 2
ERLIN2 ER lipid raft associated 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXOSC4 exosome component 4
FAM216A family with sequence similarity 216, member A
GTSE1 G-2 and S-phase expressed 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC10 homeobox C10
IGSF3 immunoglobulin superfamily, member 3
INTS3 integrator complex subunit 3
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIFC1 kinesin family member C1
KPNB1 karyopherin (importin) beta 1
LBR lamin B receptor
LIMCH1 LIM and calponin homology domains 1
MCM10 minichromosome maintenance complex component 10
MEGF9 multiple EGF-like-domains 9
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MLPH melanophilin
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSH2 mutS homolog 2
NARFL nuclear prelamin A recognition factor-like
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
NOTCH2 notch 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUP37 nucleoporin 37kDa
OIP5 Opa interacting protein 5
OPN3 opsin 3
ORC3 origin recognition complex, subunit 3
PBK PDZ binding kinase
PCID2 PCI domain containing 2
PCM1 pericentriolar material 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PSRC1 proline/serine-rich coiled-coil 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PURA purine-rich element binding protein A
RAD21 RAD21 homolog (S. pombe)
RAD54B RAD54 homolog B (S. cerevisiae)
RBM34 RNA binding motif protein 34
RBPMS RNA binding protein with multiple splicing
RHOT1 ras homolog family member T1
RNF13 ring finger protein 13
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SH3BP4 SH3-domain binding protein 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
STAMBP STAM binding protein
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TARP TCR gamma alternate reading frame protein
TBC1D31 TBC1 domain family, member 31
TBL1X transducin (beta)-like 1X-linked
TERF2 telomeric repeat binding factor 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TMEM5 transmembrane protein 5
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAK2 trafficking protein, kinesin binding 2
TRIP6 thyroid hormone receptor interactor 6
TROAP trophinin associated protein
TRPS1 trichorhinophalangeal syndrome I
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF185 zinc finger protein 185 (LIM domain)
ZNF638 zinc finger protein 638
ZWILCH zwilch kinetochore protein