BRD-K04546108_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

325 genes differentially expressed following the BRD-K04546108_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ALB albumin
ANXA1 annexin A1
APLP1 amyloid beta (A4) precursor-like protein 1
AREG amphiregulin
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
ATG12 autophagy related 12
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
AUTS2 autism susceptibility candidate 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2L1 BCL2-like 1
BIRC3 baculoviral IAP repeat containing 3
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
C1ORF115 chromosome 1 open reading frame 115
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CALML5 calmodulin-like 5
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
DPT dermatopontin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM3C family with sequence similarity 3, member C
FBXO28 F-box protein 28
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FN1 fibronectin 1
FNTA farnesyltransferase, CAAX box, alpha
GADD45A growth arrest and DNA-damage-inducible, alpha
GPM6B glycoprotein M6B
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HOPX HOP homeobox
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFNGR1 interferon gamma receptor 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
INSR insulin receptor
IPO13 importin 13
ITGAV integrin, alpha V
JAG1 jagged 1
KIF3B kinesin family member 3B
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LINC00341 long intergenic non-protein coding RNA 341
LPAR1 lysophosphatidic acid receptor 1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LPIN1 lipin 1
MAP1B microtubule-associated protein 1B
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
NELL2 NEL-like 2 (chicken)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHF20 PHD finger protein 20
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLIN2 perilipin 2
PLXNA1 plexin A1
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
PROSC proline synthetase co-transcribed homolog (bacterial)
PTHLH parathyroid hormone-like hormone
PTRF polymerase I and transcript release factor
RBM6 RNA binding motif protein 6
RBP4 retinol binding protein 4, plasma
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RTN1 reticulon 1
RYBP RING1 and YY1 binding protein
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SNX6 sorting nexin 6
STAB1 stabilin 1
STX1A syntaxin 1A (brain)
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYBU syntabulin (syntaxin-interacting)
TF transferrin
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TOB1 transducer of ERBB2, 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TWIST1 twist family bHLH transcription factor 1
VCL vinculin
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR47 WD repeat domain 47
WIPF2 WAS/WASL interacting protein family, member 2
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD11 abhydrolase domain containing 11
ADSL adenylosuccinate lyase
AGR2 anterior gradient 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALG6 ALG6, alpha-1,3-glucosyltransferase
ALG8 ALG8, alpha-1,3-glucosyltransferase
AMDHD2 amidohydrolase domain containing 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APITD1 apoptosis-inducing, TAF9-like domain 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APRT adenine phosphoribosyltransferase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
B9D1 B9 protein domain 1
BAG2 BCL2-associated athanogene 2
BCCIP BRCA2 and CDKN1A interacting protein
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF120 chromosome 6 open reading frame 120
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPM centromere protein M
CEP55 centrosomal protein 55kDa
CIRBP cold inducible RNA binding protein
CLDN3 claudin 3
CNPY2 canopy FGF signaling regulator 2
COL5A1 collagen, type V, alpha 1
COMMD4 COMM domain containing 4
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DZIP3 DAZ interacting zinc finger protein 3
EFCAB11 EF-hand calcium binding domain 11
EIF4B eukaryotic translation initiation factor 4B
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ETFB electron-transfer-flavoprotein, beta polypeptide
FAM216A family with sequence similarity 216, member A
GALE UDP-galactose-4-epimerase
GCAT glycine C-acetyltransferase
GCDH glutaryl-CoA dehydrogenase
GFRA1 GDNF family receptor alpha 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTZ1 glutathione S-transferase zeta 1
H2AFV H2A histone family, member V
H2AFZ H2A histone family, member Z
HAUS4 HAUS augmin-like complex, subunit 4
HMGB2 high mobility group box 2
HMGN2 high mobility group nucleosomal binding domain 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPB8 heat shock 22kDa protein 8
IGFBP5 insulin-like growth factor binding protein 5
IGLV2-23 immunoglobulin lambda variable 2-23
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRX5 iroquois homeobox 5
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LOX lysyl oxidase
LRP10 low density lipoprotein receptor-related protein 10
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MRPL12 mitochondrial ribosomal protein L12
MRPL20 mitochondrial ribosomal protein L20
MRPL23 mitochondrial ribosomal protein L23
MRPL3 mitochondrial ribosomal protein L3
MRPL40 mitochondrial ribosomal protein L40
MRPS16 mitochondrial ribosomal protein S16
MRPS28 mitochondrial ribosomal protein S28
MRPS33 mitochondrial ribosomal protein S33
MRPS7 mitochondrial ribosomal protein S7
MUC1 mucin 1, cell surface associated
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NEFH neurofilament, heavy polypeptide
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO2 NAD(P)H dehydrogenase, quinone 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
NUPR1 nuclear protein, transcriptional regulator, 1
ORC3 origin recognition complex, subunit 3
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXLD1 oxidoreductase-like domain containing 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PCYOX1L prenylcysteine oxidase 1 like
PDCD2 programmed cell death 2
PER3 period circadian clock 3
PEX10 peroxisomal biogenesis factor 10
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PNKP polynucleotide kinase 3'-phosphatase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPA2 pyrophosphatase (inorganic) 2
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRMT5 protein arginine methyltransferase 5
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTGES2 prostaglandin E synthase 2
PTTG1 pituitary tumor-transforming 1
RBKS ribokinase
RER1 retention in endoplasmic reticulum sorting receptor 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RUVBL1 RuvB-like AAA ATPase 1
S100A6 S100 calcium binding protein A6
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SMC4 structural maintenance of chromosomes 4
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
SVIL supervillin
TACC3 transforming, acidic coiled-coil containing protein 3
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TMCO6 transmembrane and coiled-coil domains 6
TMEM134 transmembrane protein 134
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTK TTK protein kinase
TYMS thymidylate synthetase
U2SURP U2 snRNP-associated SURP domain containing
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR6 WD repeat domain 6
WDR61 WD repeat domain 61
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein