BRD-K04546108_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K04546108_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANOS1 anosmin 1
ANXA10 annexin A10
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
BTG3 BTG family, member 3
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
CPQ carboxypeptidase Q
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DPT dermatopontin
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EREG epiregulin
FAM46A family with sequence similarity 46, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GBE1 glucan (1,4-alpha-), branching enzyme 1
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPC4 glypican 4
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL13RA1 interleukin 13 receptor, alpha 1
INPP1 inositol polyphosphate-1-phosphatase
INSM1 insulinoma-associated 1
ITGAV integrin, alpha V
JAG1 jagged 1
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
LPPR4 lipid phosphate phosphatase-related protein type 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPPED2 metallophosphoesterase domain containing 2
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCLO piccolo presynaptic cytomatrix protein
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RCAN1 regulator of calcineurin 1
RTN1 reticulon 1
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SFN stratifin
SH3BGRL SH3 domain binding glutamate-rich protein like
SORT1 sortilin 1
SPRY2 sprouty homolog 2 (Drosophila)
SSPN sarcospan
SST somatostatin
STC1 stanniocalcin 1
SUSD4 sushi domain containing 4
SYBU syntabulin (syntaxin-interacting)
TCTN1 tectonic family member 1
THBS1 thrombospondin 1
TMOD1 tropomodulin 1
TXNIP thioredoxin interacting protein
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARFIP2 ADP-ribosylation factor interacting protein 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CLCA2 chloride channel accessory 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNOT7 CCR4-NOT transcription complex, subunit 7
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GEMIN2 gem (nuclear organelle) associated protein 2
GSTA4 glutathione S-transferase alpha 4
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KRT18 keratin 18, type I
LIMA1 LIM domain and actin binding 1
MCM10 minichromosome maintenance complex component 10
MEGF9 multiple EGF-like-domains 9
MGLL monoglyceride lipase
MRPS2 mitochondrial ribosomal protein S2
MSH2 mutS homolog 2
NMI N-myc (and STAT) interactor
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PDS5A PDS5 cohesin associated factor A
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RAD23B RAD23 homolog B (S. cerevisiae)
RAE1 ribonucleic acid export 1
RBPMS RNA binding protein with multiple splicing
RHOB ras homolog family member B
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC4 structural maintenance of chromosomes 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
UBE3C ubiquitin protein ligase E3C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VSNL1 visinin-like 1
XPO7 exportin 7
ZNF451 zinc finger protein 451