BRD-K04412738_tramadol_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K04412738_tramadol_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
CA2 carbonic anhydrase II
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD200 CD200 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CERK ceramide kinase
CFB complement factor B
CHN2 chimerin 2
CLC Charcot-Leyden crystal galectin
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DOK5 docking protein 5
FBXL12 F-box and leucine-rich repeat protein 12
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FRY furry homolog (Drosophila)
FST follistatin
FZD1 frizzled class receptor 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBP1 guanylate binding protein 1, interferon-inducible
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HBE1 hemoglobin, epsilon 1
HHEX hematopoietically expressed homeobox
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HSPA4 heat shock 70kDa protein 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
KIAA1551 KIAA1551
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NELL2 NEL-like 2 (chicken)
NSG1 neuron specific gene family member 1
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEA15 phosphoprotein enriched in astrocytes 15
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
RNASE6 ribonuclease, RNase A family, k6
RPS5 ribosomal protein S5
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
THY1 Thy-1 cell surface antigen
TMEM30B transmembrane protein 30B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CAPNS1 calpain, small subunit 1
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLTC clathrin, heavy chain (Hc)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPRC5A G protein-coupled receptor, class C, group 5, member A
LAMP1 lysosomal-associated membrane protein 1
LIF leukemia inhibitory factor
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PLAC8 placenta-specific 8
PLEC plectin
PRR7 proline rich 7 (synaptic)
PTGES prostaglandin E synthase
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
WIF1 WNT inhibitory factor 1