BRD-K03857568_1-Methyl-3-nitro-4-p-tolylsulfanyl-1H-quinolin-2-one BRD-K03857568_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K03857568_1-Methyl-3-nitro-4-p-tolylsulfanyl-1H-quinolin-2-one BRD-K03857568_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CD24 CD24 molecule
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CLCA4 chloride channel accessory 4
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA1 glutathione S-transferase alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP5 insulin-like growth factor binding protein 5
IL18 interleukin 18
KLF5 Kruppel-like factor 5 (intestinal)
KRT13 keratin 13, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
MALL mal, T-cell differentiation protein-like
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
MIR22HG MIR22 host gene
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NDRG1 N-myc downstream regulated 1
OLFM4 olfactomedin 4
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SFN stratifin
SFTPB surfactant protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNAI2 snail family zinc finger 2
STX3 syntaxin 3
TIMP3 TIMP metallopeptidase inhibitor 3
TWIST1 twist family bHLH transcription factor 1
TXNRD1 thioredoxin reductase 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADAM10 ADAM metallopeptidase domain 10
AFP alpha-fetoprotein
AHSG alpha-2-HS-glycoprotein
APOA2 apolipoprotein A-II
ASS1 argininosuccinate synthase 1
BRCA1 breast cancer 1, early onset
C14ORF132 chromosome 14 open reading frame 132
CDKN2A cyclin-dependent kinase inhibitor 2A
CYBA cytochrome b-245, alpha polypeptide
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLG5 discs, large homolog 5 (Drosophila)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GOLGA8A golgin A8 family, member A
GPC3 glypican 3
GREB1 growth regulation by estrogen in breast cancer 1
GRP gastrin-releasing peptide
HELLS helicase, lymphoid-specific
HOXC10 homeobox C10
HSPA2 heat shock 70kDa protein 2
IFI44 interferon-induced protein 44
IQSEC1 IQ motif and Sec7 domain 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LCK LCK proto-oncogene, Src family tyrosine kinase
MACF1 microtubule-actin crosslinking factor 1
MAGEA3 melanoma antigen family A3
MAOB monoamine oxidase B
MDK midkine (neurite growth-promoting factor 2)
MRPS16 mitochondrial ribosomal protein S16
NKX2-2 NK2 homeobox 2
NPY1R neuropeptide Y receptor Y1
OLFM1 olfactomedin 1
PDE4B phosphodiesterase 4B, cAMP-specific
PEG3 paternally expressed 3
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLSCR3 phospholipid scramblase 3
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SF1 splicing factor 1
TRIB2 tribbles pseudokinase 2
VTCN1 V-set domain containing T cell activation inhibitor 1
ZMAT3 zinc finger, matrin-type 3