BRD-K03857568_1-Methyl-3-nitro-4-p-tolylsulfanyl-1H-quinolin-2-one BRD-K03857568_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K03857568_1-Methyl-3-nitro-4-p-tolylsulfanyl-1H-quinolin-2-one BRD-K03857568_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
APOC1 apolipoprotein C-I
AQP9 aquaporin 9
ARC activity-regulated cytoskeleton-associated protein
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CLDN4 claudin 4
CST6 cystatin E/M
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPHA2 EPH receptor A2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM46C family with sequence similarity 46, member C
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRS2 fibroblast growth factor receptor substrate 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
LOC100505650 uncharacterized LOC100505650
LST1 leukocyte specific transcript 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
RBBP6 retinoblastoma binding protein 6
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
THBD thrombomodulin
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
VCAN versican
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF274 zinc finger protein 274
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ASPH aspartate beta-hydroxylase
B3GNT1
C14ORF132 chromosome 14 open reading frame 132
CA12 carbonic anhydrase XII
CAPN3 calpain 3, (p94)
CBR3 carbonyl reductase 3
CDC20 cell division cycle 20
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COX11 COX11 cytochrome c oxidase copper chaperone
CXCL5 chemokine (C-X-C motif) ligand 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DHRS1 dehydrogenase/reductase (SDR family) member 1
DPYSL2 dihydropyrimidinase-like 2
DUSP3 dual specificity phosphatase 3
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HOXB7 homeobox B7
HOXC6 homeobox C6
KLHL9 kelch-like family member 9
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100272216 uncharacterized LOC100272216
LPCAT1 lysophosphatidylcholine acyltransferase 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAP1B microtubule-associated protein 1B
METTL3 methyltransferase like 3
MYO5C myosin VC
NAV2 neuron navigator 2
NPTX1 neuronal pentraxin I
NQO1 NAD(P)H dehydrogenase, quinone 1
PEX11B peroxisomal biogenesis factor 11 beta
PFN2 profilin 2
PITX1 paired-like homeodomain 1
PRR11 proline rich 11
PRUNE2 prune homolog 2 (Drosophila)
RRAGD Ras-related GTP binding D
SEPT10 septin 10
SEPT6 septin 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SORBS3 sorbin and SH3 domain containing 3
SPRR1A small proline-rich protein 1A
TBCD tubulin folding cofactor D
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZW10 zw10 kinetochore protein