BRD-K03857568_1-Methyl-3-nitro-4-p-tolylsulfanyl-1H-quinolin-2-one BRD-K03857568_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K03857568_1-Methyl-3-nitro-4-p-tolylsulfanyl-1H-quinolin-2-one BRD-K03857568_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD10 ankyrin repeat domain 10
AQP1 aquaporin 1 (Colton blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BGN biglycan
BTG2 BTG family, member 2
C1ORF56 chromosome 1 open reading frame 56
C7 complement component 7
CADM1 cell adhesion molecule 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLIC4 chloride intracellular channel 4
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF9 fibroblast growth factor 9
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
HBB hemoglobin, beta
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGL immunoglobulin lambda locus
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPARCL1 SPARC-like 1 (hevin)
STK10 serine/threonine kinase 10
TARP TCR gamma alternate reading frame protein
TFF3 trefoil factor 3 (intestinal)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZC3H11A zinc finger CCCH-type containing 11A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALOX5 arachidonate 5-lipoxygenase
CBR3 carbonyl reductase 3
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL5A2 collagen, type V, alpha 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMX2 empty spiracles homeobox 2
FABP7 fatty acid binding protein 7, brain
FBN1 fibrillin 1
IL13RA2 interleukin 13 receptor, alpha 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
MID1 midline 1
PLA2G16 phospholipase A2, group XVI
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TMEM47 transmembrane protein 47
TRAPPC3 trafficking protein particle complex 3
TSPAN3 tetraspanin 3
ZNF185 zinc finger protein 185 (LIM domain)