BRD-K03829970_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

294 genes differentially expressed following the BRD-K03829970_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATP10D ATPase, class V, type 10D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CD52 CD52 molecule
CD9 CD9 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
CKM creatine kinase, muscle
CLIC3 chloride intracellular channel 3
CLU clusterin
COCH cochlin
COTL1 coactosin-like F-actin binding protein 1
CTSL cathepsin L
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR2 early growth response 2
EMP3 epithelial membrane protein 3
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FAM46A family with sequence similarity 46, member A
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLA galactosidase, alpha
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GRN granulin
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
HPCAL1 hippocalcin-like 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGF2R insulin-like growth factor 2 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
JAG1 jagged 1
KCTD5 potassium channel tetramerization domain containing 5
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
LYST lysosomal trafficking regulator
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MB myoglobin
MIR22HG MIR22 host gene
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MOSPD1 motile sperm domain containing 1
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEB nebulin
NID1 nidogen 1
OPN3 opsin 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE10A phosphodiesterase 10A
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLXNB2 plexin B2
PRTN3 proteinase 3
PTPRE protein tyrosine phosphatase, receptor type, E
PTRF polymerase I and transcript release factor
REEP1 receptor accessory protein 1
RGCC regulator of cell cycle
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
STC1 stanniocalcin 1
TANK TRAF family member-associated NFKB activator
TGFB1 transforming growth factor, beta 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP2 TIMP metallopeptidase inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TNS1 tensin 1
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBE3B ubiquitin protein ligase E3B
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WAC WW domain containing adaptor with coiled-coil
WFS1 Wolfram syndrome 1 (wolframin)
XCL1 chemokine (C motif) ligand 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZNF12 zinc finger protein 12

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABLIM1 actin binding LIM protein 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMDHD2 amidohydrolase domain containing 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA7 annexin A7
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BUB3 BUB3 mitotic checkpoint protein
C14ORF2 chromosome 14 open reading frame 2
C3 complement component 3
CCNA2 cyclin A2
CDK4 cyclin-dependent kinase 4
CFB complement factor B
CHEK2 checkpoint kinase 2
CHMP4A charged multivesicular body protein 4A
CP ceruloplasmin (ferroxidase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
DCK deoxycytidine kinase
DEPTOR DEP domain containing MTOR-interacting protein
DLD dihydrolipoamide dehydrogenase
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNALI1 dynein, axonemal, light intermediate chain 1
ECI2 enoyl-CoA delta isomerase 2
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4B eukaryotic translation initiation factor 4B
ELOVL5 ELOVL fatty acid elongase 5
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GLOD4 glyoxalase domain containing 4
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTPBP8 GTP-binding protein 8 (putative)
HAUS4 HAUS augmin-like complex, subunit 4
HN1L hematological and neurological expressed 1-like
HNRNPR heterogeneous nuclear ribonucleoprotein R
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IARS isoleucyl-tRNA synthetase
IGF1R insulin-like growth factor 1 receptor
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIAA0101 KIAA0101
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA1 lysophospholipase I
LYRM4 LYR motif containing 4
MAGED2 melanoma antigen family D2
MARS methionyl-tRNA synthetase
MCTS1 malignant T cell amplified sequence 1
METTL1 methyltransferase like 1
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPL16 mitochondrial ribosomal protein L16
MRPS16 mitochondrial ribosomal protein S16
MRPS30 mitochondrial ribosomal protein S30
MRPS33 mitochondrial ribosomal protein S33
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NARS asparaginyl-tRNA synthetase
NBN nibrin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NHP2 NHP2 ribonucleoprotein
NIT2 nitrilase family, member 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOV nephroblastoma overexpressed
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP107 nucleoporin 107kDa
PAPOLA poly(A) polymerase alpha
PARP2 poly (ADP-ribose) polymerase 2
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PPA1 pyrophosphatase (inorganic) 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF19 pre-mRNA processing factor 19
PRSS2 protease, serine, 2 (trypsin 2)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QDPR quinoid dihydropteridine reductase
RBM28 RNA binding motif protein 28
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RPL22 ribosomal protein L22
RRP1B ribosomal RNA processing 1B
RSL24D1 ribosomal L24 domain containing 1
RUVBL1 RuvB-like AAA ATPase 1
SCCPDH saccharopine dehydrogenase (putative)
SCP2 sterol carrier protein 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLIRP SRA stem-loop interacting RNA binding protein
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SSBP1 single-stranded DNA binding protein 1, mitochondrial
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMELESS timeless circadian clock
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM109 transmembrane protein 109
TMEM126B transmembrane protein 126B
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TOX thymocyte selection-associated high mobility group box
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
UGCG UDP-glucose ceramide glucosyltransferase
WDR12 WD repeat domain 12
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
XPO1 exportin 1
XPOT exportin, tRNA