BRD-K03829970_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K03829970_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK4 adenylate kinase 4
ALDOB aldolase B, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ASPN asporin
ATF5 activating transcription factor 5
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CCND2 cyclin D2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLU clusterin
DCN decorin
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FGFR3 fibroblast growth factor receptor 3
FNBP1 formin binding protein 1
FOXG1 forkhead box G1
FXYD6 FXYD domain containing ion transport regulator 6
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTA1 glutathione S-transferase alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HTRA1 HtrA serine peptidase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGHM immunoglobulin heavy constant mu
MAOB monoamine oxidase B
PBX1 pre-B-cell leukemia homeobox 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PTN pleiotrophin
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
TCF4 transcription factor 4
TIMP2 TIMP metallopeptidase inhibitor 2
TXNL4B thioredoxin-like 4B

decreased expression

Symbol Name
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CCND1 cyclin D1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CKLF chemokine-like factor
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
FOSL1 FOS-like antigen 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
ITGA6 integrin, alpha 6
LYZ lysozyme
MET MET proto-oncogene, receptor tyrosine kinase
MOK MOK protein kinase
MRPL12 mitochondrial ribosomal protein L12
MSLN mesothelin
MYOF myoferlin
NEFL neurofilament, light polypeptide
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRG1 neuregulin 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OSBPL10 oxysterol binding protein-like 10
PRAME preferentially expressed antigen in melanoma
RPL22 ribosomal protein L22
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
SCAND1 SCAN domain containing 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TRAPPC3 trafficking protein particle complex 3
XPO7 exportin 7