BRD-K03816923_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K03816923_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CCNG2 cyclin G2
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC11A C-type lectin domain family 11, member A
COL15A1 collagen, type XV, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CST6 cystatin E/M
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
H1F0 H1 histone family, member 0
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IER5 immediate early response 5
IGL immunoglobulin lambda locus
ISYNA1 inositol-3-phosphate synthase 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KLK8 kallikrein-related peptidase 8
KRT23 keratin 23, type I
LTBP1 latent transforming growth factor beta binding protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MGLL monoglyceride lipase
MT1G metallothionein 1G
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
NFIL3 nuclear factor, interleukin 3 regulated
PELI1 pellino E3 ubiquitin protein ligase 1
PKP2 plakophilin 2
PLA2G16 phospholipase A2, group XVI
POSTN periostin, osteoblast specific factor
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RGCC regulator of cell cycle
RHOB ras homolog family member B
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCRG1 stimulator of chondrogenesis 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SPON2 spondin 2, extracellular matrix protein
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TMEM45A transmembrane protein 45A
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
YBX3 Y box binding protein 3
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF451 zinc finger protein 451
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
ATF5 activating transcription factor 5
AXL AXL receptor tyrosine kinase
BASP1 brain abundant, membrane attached signal protein 1
C6ORF62 chromosome 6 open reading frame 62
CD24 CD24 molecule
CDC25A cell division cycle 25A
FASTKD5 FAST kinase domains 5
GNAS GNAS complex locus
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KCTD12 potassium channel tetramerization domain containing 12
LONP2 lon peptidase 2, peroxisomal
MARCKS myristoylated alanine-rich protein kinase C substrate
MFSD10 major facilitator superfamily domain containing 10
NOP16 NOP16 nucleolar protein
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDZK1 PDZ domain containing 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLAC8 placenta-specific 8
PON3 paraoxonase 3
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SRPX sushi-repeat containing protein, X-linked
TFPI2 tissue factor pathway inhibitor 2
TLR4 toll-like receptor 4
TMEM5 transmembrane protein 5
TUSC3 tumor suppressor candidate 3