BRD-K03816923_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K03816923_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BHLHE41 basic helix-loop-helix family, member e41
CD200 CD200 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CYB5R2 cytochrome b5 reductase 2
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ENO2 enolase 2 (gamma, neuronal)
F11R F11 receptor
FAM117A family with sequence similarity 117, member A
FAM129A family with sequence similarity 129, member A
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GAGE3 G antigen 3
GATA6 GATA binding protein 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA13 heat shock protein 70kDa family, member 13
IGFBP5 insulin-like growth factor binding protein 5
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
MME membrane metallo-endopeptidase
MXI1 MAX interactor 1, dimerization protein
MZB1 marginal zone B and B1 cell-specific protein
NEU1 sialidase 1 (lysosomal sialidase)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PER3 period circadian clock 3
PRKCI protein kinase C, iota
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100P S100 calcium binding protein P
SERINC3 serine incorporator 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SULF1 sulfatase 1
TCEAL2 transcription elongation factor A (SII)-like 2
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TRIB3 tribbles pseudokinase 3
TULP3 tubby like protein 3
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFPM2 zinc finger protein, FOG family member 2
ZHX2 zinc fingers and homeoboxes 2
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BZW1 basic leucine zipper and W2 domains 1
CA12 carbonic anhydrase XII
CD320 CD320 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPB1 carboxypeptidase B1 (tissue)
CPM carboxypeptidase M
CSRP1 cysteine and glycine-rich protein 1
CST3 cystatin C
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP1 cytoplasmic FMR1 interacting protein 1
DLC1 DLC1 Rho GTPase activating protein
DUSP4 dual specificity phosphatase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GAS1 growth arrest-specific 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX1 glutathione peroxidase 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HES1 hes family bHLH transcription factor 1
HN1 hematological and neurological expressed 1
HOXB6 homeobox B6
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6ST interleukin 6 signal transducer
ITGB1BP1 integrin beta 1 binding protein 1
ITGB5 integrin, beta 5
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LHFP lipoma HMGIC fusion partner
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MAP2K3 mitogen-activated protein kinase kinase 3
MARCKSL1 MARCKS-like 1
MBNL1 muscleblind-like splicing regulator 1
MGLL monoglyceride lipase
MRPL12 mitochondrial ribosomal protein L12
MYCBP MYC binding protein
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PLIN1 perilipin 1
PLS3 plastin 3
PMP22 peripheral myelin protein 22
PON2 paraoxonase 2
PRSS23 protease, serine, 23
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PXMP2 peroxisomal membrane protein 2, 22kDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SRGN serglycin
SRPX sushi-repeat containing protein, X-linked
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM164 transmembrane protein 164
TMEM97 transmembrane protein 97
TOX3 TOX high mobility group box family member 3
TPM4 tropomyosin 4
TSPAN3 tetraspanin 3
TUBB6 tubulin, beta 6 class V