BRD-K03814443_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K03814443_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARL4C ADP-ribosylation factor-like 4C
BMP2 bone morphogenetic protein 2
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CDKN2A cyclin-dependent kinase inhibitor 2A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA4 EPH receptor A4
EXT1 exostosin glycosyltransferase 1
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLK5 kallikrein-related peptidase 5
KLK8 kallikrein-related peptidase 8
LMO4 LIM domain only 4
MAP7 microtubule-associated protein 7
MME membrane metallo-endopeptidase
NR1H2 nuclear receptor subfamily 1, group H, member 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLK2 polo-like kinase 2
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RNF167 ring finger protein 167
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLPI secretory leukocyte peptidase inhibitor
SOCS2 suppressor of cytokine signaling 2
SST somatostatin
TAGLN2 transgelin 2
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK2 ankyrin 2, neuronal
CD93 CD93 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CRISP3 cysteine-rich secretory protein 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP1 fatty acid binding protein 1, liver
GPRC5A G protein-coupled receptor, class C, group 5, member A
HCAR3 hydroxycarboxylic acid receptor 3
IGFBP1 insulin-like growth factor binding protein 1
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
IQGAP1 IQ motif containing GTPase activating protein 1
KCTD12 potassium channel tetramerization domain containing 12
LDLR low density lipoprotein receptor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK13 mitogen-activated protein kinase 13
MGP matrix Gla protein
MUC5B mucin 5B, oligomeric mucus/gel-forming
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
PVALB parvalbumin
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TM4SF1 transmembrane 4 L six family member 1
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1