BRD-K03736784_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

322 genes differentially expressed following the BRD-K03736784_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADM adrenomedullin
AHCYL2 adenosylhomocysteinase-like 2
AKIRIN1 akirin 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD11 ankyrin repeat domain 11
ANKRD12 ankyrin repeat domain 12
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C1ORF106 chromosome 1 open reading frame 106
C1QB complement component 1, q subcomponent, B chain
C20ORF24 chromosome 20 open reading frame 24
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CALR calreticulin
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CDA cytidine deaminase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL6A2 collagen, type VI, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CRCT1 cysteine-rich C-terminal 1
CSRP2 cysteine and glycine-rich protein 2
CTSB cathepsin B
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM117A family with sequence similarity 117, member A
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
INSR insulin receptor
JAG1 jagged 1
JMJD6 jumonji domain containing 6
KCMF1 potassium channel modulatory factor 1
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KPNA6 karyopherin alpha 6 (importin alpha 7)
KRT1 keratin 1, type II
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
LPIN1 lipin 1
LRP4 low density lipoprotein receptor-related protein 4
LYPD3 LY6/PLAUR domain containing 3
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K3 mitogen-activated protein kinase kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MOSPD1 motile sperm domain containing 1
MSN moesin
MSRB1 methionine sulfoxide reductase B1
NEU1 sialidase 1 (lysosomal sialidase)
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
OPN3 opsin 3
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PRDX1 peroxiredoxin 1
RGCC regulator of cell cycle
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RND3 Rho family GTPase 3
RNF10 ring finger protein 10
RNF114 ring finger protein 114
RNF24 ring finger protein 24
RRAGC Ras-related GTP binding C
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SDC3 syndecan 3
SDCBP syndecan binding protein (syntenin)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SOWAHC sosondowah ankyrin repeat domain family member C
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
STK17A serine/threonine kinase 17a
STK38 serine/threonine kinase 38
STX1A syntaxin 1A (brain)
TBX2 T-box 2
TCTA T-cell leukemia translocation altered
TDP2 tyrosyl-DNA phosphodiesterase 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOP1 topoisomerase (DNA) I
TPST2 tyrosylprotein sulfotransferase 2
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VCL vinculin
VEGFA vascular endothelial growth factor A
WFS1 Wolfram syndrome 1 (wolframin)
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YPEL5 yippee-like 5 (Drosophila)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ACLY ATP citrate lyase
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARMT1 acidic residue methyltransferase 1
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C14ORF159 chromosome 14 open reading frame 159
C21ORF33 chromosome 21 open reading frame 33
C3 complement component 3
CA9 carbonic anhydrase IX
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALML4 calmodulin-like 4
CCND1 cyclin D1
CCNO cyclin O
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
CFB complement factor B
CHMP4A charged multivesicular body protein 4A
CHN2 chimerin 2
CLDN3 claudin 3
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRIP2 cysteine-rich protein 2
CTSH cathepsin H
CYBA cytochrome b-245, alpha polypeptide
DEPTOR DEP domain containing MTOR-interacting protein
DLD dihydrolipoamide dehydrogenase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNALI1 dynein, axonemal, light intermediate chain 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUT deoxyuridine triphosphatase
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FABP6 fatty acid binding protein 6, ileal
FAM57A family with sequence similarity 57, member A
FBP1 fructose-1,6-bisphosphatase 1
FHIT fragile histidine triad
FILIP1L filamin A interacting protein 1-like
FKBP10 FK506 binding protein 10, 65 kDa
FKBP3 FK506 binding protein 3, 25kDa
FZD6 frizzled class receptor 6
GALE UDP-galactose-4-epimerase
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GMDS GDP-mannose 4,6-dehydratase
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTZ1 glutathione S-transferase zeta 1
HADH hydroxyacyl-CoA dehydrogenase
HAUS4 HAUS augmin-like complex, subunit 4
HEBP1 heme binding protein 1
HLA-DMB major histocompatibility complex, class II, DM beta
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL17RB interleukin 17 receptor B
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MACROD1 MACRO domain containing 1
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM7 minichromosome maintenance complex component 7
MGMT O-6-methylguanine-DNA methyltransferase
MGP matrix Gla protein
MLPH melanophilin
MSRB2 methionine sulfoxide reductase B2
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NBN nibrin
NFIB nuclear factor I/B
NOV nephroblastoma overexpressed
NPDC1 neural proliferation, differentiation and control, 1
NPM3 nucleophosmin/nucleoplasmin 3
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCCB propionyl CoA carboxylase, beta polypeptide
PFKM phosphofructokinase, muscle
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRDX3 peroxiredoxin 3
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGS10 regulator of G-protein signaling 10
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SYBU syntabulin (syntaxin-interacting)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIMELESS timeless circadian clock
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TKFC triokinase/FMN cyclase
TNIK TRAF2 and NCK interacting kinase
TPPP3 tubulin polymerization-promoting protein family member 3
TRIM22 tripartite motif containing 22
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
VCAN versican
VRK1 vaccinia related kinase 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFPM2 zinc finger protein, FOG family member 2
ZWINT ZW10 interacting kinetochore protein