BRD-K03736784_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K03736784_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOC1 apolipoprotein C-I
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
BCHE butyrylcholinesterase
BTG3 BTG family, member 3
C1QA complement component 1, q subcomponent, A chain
CD14 CD14 molecule
CD200 CD200 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDO1 cysteine dioxygenase type 1
CFH complement factor H
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CTNND2 catenin (cadherin-associated protein), delta 2
DDIT4 DNA-damage-inducible transcript 4
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
EDNRB endothelin receptor type B
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FILIP1L filamin A interacting protein 1-like
FKBP11 FK506 binding protein 11, 19 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FRY furry homolog (Drosophila)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAP43 growth associated protein 43
GLUL glutamate-ammonia ligase
GPRASP1 G protein-coupled receptor associated sorting protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
INHBE inhibin, beta E
INSM1 insulinoma-associated 1
ITM2A integral membrane protein 2A
JADE3 jade family PHD finger 3
KIAA0226L KIAA0226-like
KIF14 kinesin family member 14
KRT23 keratin 23, type I
LOC100505650 uncharacterized LOC100505650
LPPR1 lipid phosphate phosphatase-related protein type 1
MAOB monoamine oxidase B
MCAM melanoma cell adhesion molecule
MTSS1 metastasis suppressor 1
NGRN neugrin, neurite outgrowth associated
NRCAM neuronal cell adhesion molecule
NSG1 neuron specific gene family member 1
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PCDH17 protocadherin 17
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PDZD2 PDZ domain containing 2
PELI1 pellino E3 ubiquitin protein ligase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKX protein kinase, X-linked
PRNP prion protein
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A14 S100 calcium binding protein A14
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
TAGLN3 transgelin 3
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TWF1 twinfilin actin binding protein 1
TXNL4B thioredoxin-like 4B
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AUTS2 autism susceptibility candidate 2
BCR breakpoint cluster region
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
CBR3 carbonyl reductase 3
CD59 CD59 molecule, complement regulatory protein
CFLAR CASP8 and FADD-like apoptosis regulator
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FPGS folylpolyglutamate synthase
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GLIPR1 GLI pathogenesis-related 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
IER3 immediate early response 3
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KRT16 keratin 16, type I
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NOV nephroblastoma overexpressed
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
OBSL1 obscurin-like 1
OLFM4 olfactomedin 4
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PPIF peptidylprolyl isomerase F
PTGES prostaglandin E synthase
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
QPCT glutaminyl-peptide cyclotransferase
RAD51C RAD51 paralog C
RAD9A RAD9 homolog A (S. pombe)
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
S100A2 S100 calcium binding protein A2
SDC4 syndecan 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGSH N-sulfoglucosamine sulfohydrolase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC44A4 solute carrier family 44, member 4
SMAD3 SMAD family member 3
SPRR1A small proline-rich protein 1A
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STX1A syntaxin 1A (brain)
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM16 tripartite motif containing 16
WFDC2 WAP four-disulfide core domain 2