BRD-K03642198_AY 9944_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K03642198_AY 9944_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD10 ankyrin repeat domain 10
C14ORF1 chromosome 14 open reading frame 1
C14ORF132 chromosome 14 open reading frame 132
CCND2 cyclin D2
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DMXL2 Dmx-like 2
EBP emopamil binding protein (sterol isomerase)
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGB3 high mobility group box 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPG lipase, endothelial
LPAR6 lysophosphatidic acid receptor 6
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MMP11 matrix metallopeptidase 11
MMP2 matrix metallopeptidase 2
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLSCR1 phospholipid scramblase 1
PPAP2B phosphatidic acid phosphatase type 2B
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STMN2 stathmin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TKT transketolase
TLK2 tousled-like kinase 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TRAPPC6A trafficking protein particle complex 6A
TSC22D3 TSC22 domain family, member 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VSNL1 visinin-like 1
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ADM adrenomedullin
ALG8 ALG8, alpha-1,3-glucosyltransferase
APOA1 apolipoprotein A-I
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
AUTS2 autism susceptibility candidate 2
C10ORF10 chromosome 10 open reading frame 10
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CFLAR CASP8 and FADD-like apoptosis regulator
COCH cochlin
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CRYAB crystallin, alpha B
CX3CL1 chemokine (C-X3-C motif) ligand 1
DUSP22 dual specificity phosphatase 22
EDN1 endothelin 1
EPHA3 EPH receptor A3
FOLR1 folate receptor 1 (adult)
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
HILPDA hypoxia inducible lipid droplet-associated
JCHAIN joining chain of multimeric IgA and IgM
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LOX lysyl oxidase
LPL lipoprotein lipase
MAP2K3 mitogen-activated protein kinase kinase 3
MYCBP MYC binding protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OXTR oxytocin receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PFKP phosphofructokinase, platelet
PLIN2 perilipin 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RBP1 retinol binding protein 1, cellular
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TIMP3 TIMP metallopeptidase inhibitor 3
TMED5 transmembrane emp24 protein transport domain containing 5
TMEM45A transmembrane protein 45A
TPM4 tropomyosin 4
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TXNDC9 thioredoxin domain containing 9
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
WDR1 WD repeat domain 1
YME1L1 YME1-like 1 ATPase