BRD-K03557653_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K03557653_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BAG3 BCL2-associated athanogene 3
CCDC47 coiled-coil domain containing 47
CD93 CD93 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLDN3 claudin 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FGG fibrinogen gamma chain
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI30 interferon, gamma-inducible protein 30
MCAM melanoma cell adhesion molecule
MMP12 matrix metallopeptidase 12
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNKP polynucleotide kinase 3'-phosphatase
POPDC3 popeye domain containing 3
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RUFY3 RUN and FYVE domain containing 3
SQSTM1 sequestosome 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AQP1 aquaporin 1 (Colton blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCHE butyrylcholinesterase
BMP4 bone morphogenetic protein 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CETN2 centrin, EF-hand protein, 2
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FST follistatin
GATA2 GATA binding protein 2
GREM1 gremlin 1, DAN family BMP antagonist
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL17RB interleukin 17 receptor B
KRT5 keratin 5, type II
MGST3 microsomal glutathione S-transferase 3
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NREP neuronal regeneration related protein
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
OSR2 odd-skipped related transciption factor 2
PCP4 Purkinje cell protein 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIH1D1 PIH1 domain containing 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM110 transmembrane protein 110
VTCN1 V-set domain containing T cell activation inhibitor 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble