BRD-K03449891_foretinib_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-K03449891_foretinib_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADCK3 aarF domain containing kinase 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX6 armadillo repeat containing, X-linked 6
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP9A ATPase, class II, type 9A
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CFB complement factor B
CHRDL1 chordin-like 1
CP ceruloplasmin (ferroxidase)
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM13A family with sequence similarity 13, member A
FAM60A family with sequence similarity 60, member A
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPX3 glutathione peroxidase 3
GSN gelsolin
HNMT histamine N-methyltransferase
HOOK2 hook microtubule-tethering protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI6 interferon, alpha-inducible protein 6
IL17RB interleukin 17 receptor B
ISG15 ISG15 ubiquitin-like modifier
KDM5B lysine (K)-specific demethylase 5B
KYNU kynureninase
LDOC1 leucine zipper, down-regulated in cancer 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MST1 macrophage stimulating 1
MVP major vault protein
N4BP2L1 NEDD4 binding protein 2-like 1
NFIB nuclear factor I/B
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PDGFC platelet derived growth factor C
PECR peroxisomal trans-2-enoyl-CoA reductase
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPCS phosphopantothenoylcysteine synthetase
PROM1 prominin 1
PRSS8 protease, serine, 8
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASET2 ribonuclease T2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC22A18 solute carrier family 22, member 18
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYBU syntabulin (syntaxin-interacting)
TACC2 transforming, acidic coiled-coil containing protein 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMPRSS3 transmembrane protease, serine 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D1 TSC22 domain family, member 1
TSPAN31 tetraspanin 31
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
WLS wntless Wnt ligand secretion mediator
YBX3 Y box binding protein 3

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK1 checkpoint kinase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EGR1 early growth response 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
IARS isoleucyl-tRNA synthetase
ITGB1BP1 integrin beta 1 binding protein 1
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NCBP1 nuclear cap binding protein subunit 1, 80kDa
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
RAD51 RAD51 recombinase
RFC3 replication factor C (activator 1) 3, 38kDa
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPIN TIMELESS interacting protein
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)