BRD-K03449891_foretinib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K03449891_foretinib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACSL5 acyl-CoA synthetase long-chain family member 5
ANXA11 annexin A11
BBX bobby sox homolog (Drosophila)
CARS cysteinyl-tRNA synthetase
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
DAPK1 death-associated protein kinase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
EGFR epidermal growth factor receptor
ERBB3 erb-b2 receptor tyrosine kinase 3
GPX2 glutathione peroxidase 2
HIST1H2AC histone cluster 1, H2ac
IGF1R insulin-like growth factor 1 receptor
IGKC immunoglobulin kappa constant
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0753 KIAA0753
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LEPROT leptin receptor overlapping transcript
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LY96 lymphocyte antigen 96
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MVP major vault protein
NAV2 neuron navigator 2
PHACTR2 phosphatase and actin regulator 2
PSAT1 phosphoserine aminotransferase 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STAB1 stabilin 1
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
CA2 carbonic anhydrase II
CCNE2 cyclin E2
CCNF cyclin F
CD200 CD200 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC6 cell division cycle 6
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA3 EPH receptor A3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
H2AFX H2A histone family, member X
HIST1H2BG histone cluster 1, H2bg
KRT19 keratin 19, type I
MAGEB2 melanoma antigen family B2
MAOB monoamine oxidase B
MCM2 minichromosome maintenance complex component 2
MSLN mesothelin
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RACGAP1 Rac GTPase activating protein 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SFRP1 secreted frizzled-related protein 1
SYNM synemin, intermediate filament protein
TMEM97 transmembrane protein 97
TPBG trophoblast glycoprotein
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein